Research Centre Rez in the Czech Republic has carried out a number of research and development activities on the nuclear technology of the fusion reactor International Thermonuclear Experimental Reactor (ITER). These contributions have led to the development of numerous experimental facilities. The initial experimental research related to ITER was focused on the technology of the LiPb eutectic alloy, and a production unit and technological channel were constructed. At a later time, material tests were performed in the neutron field of the LVR-15 research nuclear reactor. Interactions of EUROFER 97 and the LiPb eutectic alloy were examined in in-pile and out-pile tests, and the technology of the LiPb was developed. First wall mock-ups were in-pile and out-pile tested under high heat flux (HHF) cycle loads. At present, a full-size mock-up of the ITER Test Blanket System (TBS) and an HHF testing complex are constructed. This paper provides an overview of the research activities and experimental facilities.