Standards, guidelines, manuals and researches, refer mainly to the required protection of a nuclear power plant (NPP) containment structure (where the reactor's vessel is located) against different internal and external extreme events. However, there is no consideration regarding the man-made extreme event of external explosion resulting from air bomb or cruise missile. A novel Integrated Blast Resistance Model (IBRM) of NPP's reinforced concrete (RC) auxiliary facilities due to an external above ground explosion based on two components is suggested. The first is structural dynamic response analysis to the positive phase of an external explosion based on the single degree of freedom (SDOF) method combined with spalling and breaching empirical correlations. The second is in-structure shock analysis, resulted from direct-induced ground shock and air-induced ground shock. As a case study, the resistance of Westinghouse commercial NPP AP1000 control room, including a representative equipment, to an external explosion of Scud B-100 at various stand-off distances ranging from 250m (far range) till contact, was analyzed. The structure's damage level is based on its front wall supports' angle of rotation and the ductility ratio. Due to the lack of specific structural damage demands and equipment's dynamic capacities, common protective structures standards and manuals are used while requiring that no spalling nor breaching shall occur as well as remaining in the elastic regime. The IBRM may be used in wider researches concerning other NPP's auxiliary facilities and systems based upon their specifications.