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Special Section Papers

# A Study of the External Exposure Decay Curves as a Function of Several Clinical Parameters for Patients Treated With Therapeutic 131I

[+] Author and Article Information
Dimitry Ginzburg

Rotem Industries, Ltd.,
Rotem Industrial Park,
Mishor Yamin D.N. Arava
8680600, Israel
e-mail: dimgiz@rotemi.co.il

Sophia Lantsberg

Institute of Nuclear Medicine,
Soroka University Medical Center,
Beer Sheva 84101, Israel
e-mail: SophieL@clalit.org.il

Sergio Faermann

Tel Aviv 6935645, Israel
e-mail: sergio@post.bgu.ac.il

1Corresponding author.

Manuscript received August 30, 2016; final manuscript received April 2, 2017; published online May 25, 2017. Assoc. Editor: Jean Koch.

ASME J of Nuclear Rad Sci 3(3), 030906 (May 25, 2017) (4 pages) Paper No: NERS-16-1095; doi: 10.1115/1.4036433 History: Received August 30, 2016; Revised April 02, 2017

## Abstract

Hyperthyroid and thyroid carcinoma patients treated with radioactive 131I (RAI) are a potential source of external and internal exposure to members of the public, to medical staff and especially to family members, who are in close contact with these patients. The relationship between radiation dose rates and various clinical parameters, including gender, age, thyroid size and weight, and iodine uptake, was assessed. Dose rates were measured on eight patients with thyroid carcinoma after total or subtotal thyroidectomy and on six patients with hyperthyroidism. All measurements were taken at 1 m from the patient on two levels—anterior to the neck and body center. Dose rates were measured at three or four times—at the time of RAI administration, and after 24 h, 48 h, and 168 h. Based on these measurements, retention curves were obtained. The effective half-life was derived by fitting an exponential equation and was estimated to be 12.8 h.

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## References

Cappelen, T. , and Unhjem, J. F. , 2009, “ Use of 131-Iodine and the Risk of Radiation Exposure: Potential Hazards to the Patient and Other People,” Comprehensive Handbook of Iodine, V. R. Preedy , G. N. Burrow , and R. Watson , eds., Academic Press, San Diego, CA, Chap. 100.
McDougall, I. R. , 1992, Thyroid Disease in Clinical Practice, Chapman & Hall, London, UK.
ICRP, 1988, Radiation Dose to Patients From Radiopharmaceuticals, Elsevier Science, Oxford, UK.
Ministry of Health, 2002, “ Regulatory Guide—Release of Patients Administered Iodine 131,” Ministry of Health 0064/2002, Jerusalem, Israel (in Hebrew).
NCRP, 2006, Management of Radionuclide Therapy Patients, NCRP, Bethesda, MD, Report No. 155.
Thermo Scientific, 2007, “ Bicron Micro Rem Tissue Equivalent Survey Meter,” Specification Sheet, Thermo Scientific, Erlangen, Germany.
Willegaignon, J. , Guimaraes, M. I. C. , Malvestiti, L. F. , Sordi, G. M. A. A. , Sapienza, M. T. , Neto, G. C. , and Marone, M. , 2005, “ Monitoramento de Pacientes em Medicine Nuclear,” Anais do X Congresso Brasileiro de Física Médica, Salvador, Brazil, June 25–26, Paper No. 19.
Willegaignon, J. , Malvestiti, L. F. , Guimaraes, M. I. C. , Sapienza, M. T. , Endo, I. S. , Neto, G. C. , Marone, M. , and Sordi, G. M. A. A. , 2006, “ 131I Effective Half-Life (Teff) for Patients With Thyroid Cancer,” Health Phys., 91(2), pp. 119–122. [PubMed]

## Figures

Fig. 1

Average dose rate versus time measured from patients with thyroid cancer at 1 m anterior to the neck and to the body center. The bold line corresponds to the dose rate under which the Regulatory Guide of the Israeli Ministry of Health allows release of the patient from the hospital.

Fig. 2

Dose rate as a function of time and gender of the patients with thyroid cancer

Fig. 3

Dose rate as a function of time and age of the patients with thyroid cancer

Fig. 4

Dose rate as a function of time and gender of the patients with hyperthyroidism

Fig. 5

Dose rate as a function of time and uptake for patients with hyperthyroidism

Fig. 6

Dose rate as a function of time and age of the patients with hyperthyroidism

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