Convection-Enhanced Delivery (CED) is an investigative treatment for brain tumors. Reflux has been shown to be a key issue in the success of CED treatments. Minimal research has been conducted to determine the onset of reflux. Furthermore, the ability to identify reflux allows for corrective action to be taken before the consequences of reflux renders the treatment unsuccessful. Reflux could be quickly identified by changes in pressure measured in the catheter. In this study we examine the difficulties associated with measuring inline pressure. Results indicate the measured inline pressure will change depending on catheter length and orientation. Therefore, relative changes in pressure coupled with early treatment imaging could be utilized to determine the success of CED treatment.