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Keywords: Convection-Enhanced Delivery
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Proceedings Papers

Burst, Leakage, and Constant Pressure Infusion Testing of a Convection Enhanced Drug Delivery System for Glioblastoma Treatment

Iman Salafian, Christopher G. Rylander
Proc. ASME. DMD2022, 2022 Design of Medical Devices Conference, V001T10A006, April 11–14, 2022
Paper No: DMD2022-1060
DOI: https://doi.org/10.1115/DMD2022-1060
... Abstract Convection-enhanced delivery (CED) through an arborizing microneedle catheter system is an experimental drug delivery technique used to treat glioblastoma by providing a higher drug volume dispersed (Vd) of therapeutics directly to larger regions of brain tissue. A convection-enhanced...
View Paper titled, Burst, Leakage, and Constant Pressure Infusion Testing of a Convection Enhanced Drug Delivery System for Glioblastoma Treatment
Click here to open pdf in another window PDF for Burst, Leakage, and Constant Pressure Infusion Testing of a Convection Enhanced Drug Delivery System for Glioblastoma Treatment
Topics: Catheters, Convection, Drug delivery systems, Fibers, Flow (Dynamics), Food and Drug Administration, Frequency-domain analysis, Leakage, Microneedles, Pressure
Proceedings Papers

Evaluating The Dispersal Volume of a Six-Port Arborizing Catheter in Agarose as a Function of Infusion Flow Rate and Catheter Retraction Speed

Etse-Oghena Y. Campbell, Fang-Chi Hsu, Christopher G. Rylander
Proc. ASME. DMD2022, 2022 Design of Medical Devices Conference, V001T10A005, April 11–14, 2022
Paper No: DMD2022-1057
DOI: https://doi.org/10.1115/DMD2022-1057
... Abstract Convection-enhanced delivery (CED) is an emerging method for treating highly aggressive and infiltrative forms of brain cancer, like glioblastomas. However, drawbacks of utilizing CED include limited availability of tools capable of bypassing the blood-brain barrier and blood-brain...
View Paper titled, Evaluating The Dispersal Volume of a Six-Port Arborizing Catheter in Agarose as a Function of Infusion Flow Rate and Catheter Retraction Speed
Click here to open pdf in another window PDF for Evaluating The Dispersal Volume of a Six-Port Arborizing Catheter in Agarose as a Function of Infusion Flow Rate and Catheter Retraction Speed
Topics: Agar, Catheters, Convection, Flow (Dynamics)
Proceedings Papers

Measuring Line Pressure in Convection-Enhanced Delivery Infusions

Jason N. Mehta, Brianna E. Morales, Christopher G. Rylander
Proc. ASME. DMD2021, 2021 Design of Medical Devices Conference, V001T12A012, April 12–15, 2021
Paper No: DMD2021-1083
DOI: https://doi.org/10.1115/DMD2021-1083
... Abstract Convection-Enhanced Delivery (CED) is an investigative treatment for brain tumors. Reflux has been shown to be a key issue in the success of CED treatments. Minimal research has been conducted to determine the onset of reflux. Furthermore, the ability to identify reflux allows...
View Paper titled, Measuring Line Pressure in <span class="search-highlight">Convection</span>-<span class="search-highlight">Enhanced</span> <span class="search-highlight">Delivery</span> Infusions
Click here to open pdf in another window PDF for Measuring Line Pressure in <span class="search-highlight">Convection</span>-<span class="search-highlight">Enhanced</span> <span class="search-highlight">Delivery</span> Infusions
Topics: Convection, Pressure
Proceedings Papers

Computational Model of a Two Material Object Predicts Non-Symmetric Dispersal Volume Profile

Brianna E. Morales, Jason N. Mehta, Christopher G. Rylander
Proc. ASME. DMD2021, 2021 Design of Medical Devices Conference, V001T12A014, April 12–15, 2021
Paper No: DMD2021-1087
DOI: https://doi.org/10.1115/DMD2021-1087
... Abstract Convection-enhanced delivery (CED) is an experimental method of localized treatment to release high concentrations of the drug into a target area. An implementation of CED by our lab is the convection-enhanced thermo-therapy catheter system (CETCS). The device is a collection...
View Paper titled, Computational Model of a Two Material Object Predicts Non-Symmetric Dispersal Volume Profile
Click here to open pdf in another window PDF for Computational Model of a Two Material Object Predicts Non-Symmetric Dispersal Volume Profile
Topics: Computer simulation, Convection, Microneedles