The problem of adaptive noise cancellation in an acoustic duct is discussed. An adaptive controller design approach based on parametrizing the set of stabilizing controllers using the Youla parametrization and tuning the Youla parameter to achieve regulation is presented. Three controller adaptation algorithms are implemented to solve the noise cancellation problem in an acoustic duct. The experimental results indicate a mixed performance for each of the adaptation algorithms, with good performances observed only in some frequency ranges. The discrepancy between the expected and the observed performances is attributed to unmodeled nonlinearities in the speakers.