In recent years cellular biomechanics has attracted much attention in various fields including biology, medicine, and engineering. Although the ability of a cell to sense and respond to mechanical forces is a focus of many investigations, determining the specifics of how a mechanical stimulus directly affects the behavior and function of a living cell remains a daunting task. Here, by combining the chip technology that is able to create structures on the same size scale as cells, a biological microelectromechanical systems (BioMEMS) device is developed and utilized to study the force generation, local perturbation and deformation of a single cell.

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