In an effort to better understand the role of mechanical loading on the healing and remodeling of biological tissues, a number of in vitro models have been developed to apply either static or cyclic mechanical load to cell-seeded scaffolds (Huang 1993, Langelier 1999, Cacou 2000). The current study describes the validation of a new system designed to facilitate the study of matrix remodeling in cell seeded scaffolds, as well as the formation of tissue engineered scaffolds for potential use in repair of healing ligaments and tendons. Our objective was to develop a system that would allow a cell seeded scaffold to remain viable under cyclic loading for long periods of time, with the capability to apply complex loading regimes to the scaffold while monitoring the load in the scaffold.
Development of a Novel Model System to Study Remodeling of ECM Scaffolds in Response to Cyclic Stretching
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Gilbert, TW, Wang, JH, Badylak, SF, & Woo, SL. "Development of a Novel Model System to Study Remodeling of ECM Scaffolds in Response to Cyclic Stretching." Proceedings of the ASME 2003 International Mechanical Engineering Congress and Exposition. Advances in Bioengineering. Washington, DC, USA. November 15–21, 2003. pp. 395-396. ASME. https://doi.org/10.1115/IMECE2003-41444
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