Estimating effective thermal damage process coefficients for the first order kinetic model of damage processes is not difficult when the temperature is held constant for a substantial period. Laser coagulation experiments, however, are of short duration and, because of non uniform beam profiles, exhibit important heat transfer effects: the thermal histories are transient by nature and spatial temperature gradients are significant. Estimates of activation energy, E, and collision frequency factor, A, were obtained from transient laser exposure of freshly-excised rabbit myocardium. The transient exposures were converted to equivalent constant temperature exposures using A-E plane plots. The equivalent constant temperature conditions were then plotted on standard Arrhenius axes to estimate the activation energy, E (kj/mole) and frequency factor, A (1/s).

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