This review paper covers the subject of vehicle design for protection against the blast of improvised explosive devices. It summarizes the most recent techniques in the design of vehicle structures for blast protection. This review pinpoints the challenges in designing a vehicle for blast protection and maintaining acceptable mobility at the same time. In addition, this paper reveals and summarizes key design principles based on the critical assessment of the published literature. This review covers the state of the art design methods for each individual part of vehicle structure. It also identifies the role of human protective gear and its effectiveness in mitigating blast related injuries. This review suggests future trends in developing innovative protective structures that are inspired by nature or manufactured. The aim of this review is to guide and advance the research of vehicle design for blast protection.