Stereotactic localization using multimodality of medical images (such as CT or MRI) is increasingly employed to guide neurosurgical procedures 1,2,3,5. This technique provides highly accurate intraoperative localization and allows the surgeon to resect a lesion in its entirety while sparing critical areas of the brain. Image guided interactive frameless stereotaxy has been successfully applied to intracranial surgery and spine surgery. It has demonstrated a potential for reducing both operative time and morbidity. In this paper we described our interactive image guided surgery system and the experience of appling to different kind of surgery.