The goal of the current study was to develop a computational method that provides blood-tissue interaction under physiologic Reynolds numbers, which required a modest amount of computational resources. To accomplish this goal, the Immersed Boundary Method was used to provide blood-tissue interaction in response to fluid forces and changes in tissue pathophysiology. The fluid conservation equations were solved by Patankar’s Semi-Implicit Method for Pressure Linked Equations (SIMPLE) to provide solution stability. These methods were applied to two thin-walled, truncated ellipsoid models that contracted over a 100 msec period, with only the orifice area differing (ratio of 2:1). By combining the two methods, the simulations were performed at physiologic Reynolds numbers, and required only 24 Mb of memory. In addition, the results predicted the expected behavior of the smaller annulus model requiring a higher ejection pressure and ejecting less volume for the same input function for controlling fiber contraction.

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