Strength mismatched pipes with part-through cracks can suffer large plastic deformation from permanent ground deformations caused by geohazards. Thus, the crack driving force involved in engineering critical assessments plays an important role in guaranteeing pipeline integrity when pipes are subjected to complex loads induced by a hostile environment. In this paper, Python scripts are developed to generate up to 200 finite element models of strength mismatched pipes with various crack sizes under large plastic deformations based on the commercial software ABAQUS. The effects of crack length, crack depth, and strength mismatch factors on the evolution of crack tip opening displacement (CTOD) and global strain were investigated. An approximately linear relationship was observed in all cases tested with global strain values varying from 0.5% to 3%. Meanwhile, the value of the CTOD increased with the increase of crack length and crack depth, and decreased with increasing mismatch factor from the undermatch to the overmatch conditions. The effect of the crack depth on the CTOD is comparatively larger than the crack length, which presented an obvious change of the CTOD for deep cracks coupled with undermatched conditions. Overmatched welding only affected the value of CTOD slightly, while a drastic increase of CTOD value was observed for the undermatched welding conditions, especially for deep and long cracks.