Under normal physiological conditions platelets circulate in the plasma of blood and respond to vessel injury by changing shape, secreting granule contents and aggregating . The activation of platelets in diseased or occluded arteries can form thrombosis causing a heart attack or stroke . Shear stress activation has been suggested as an important contributor to increased platelet activation and adhesion seen in regions of stenosis.
Platelet and Shear Stress Interactions Within Asymmetric Stenotic Arteries
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Shrum, J, Merhi, Y, & Leask, RL. "Platelet and Shear Stress Interactions Within Asymmetric Stenotic Arteries." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 203-204. ASME. https://doi.org/10.1115/SBC2007-176446
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