The clinical efficacy of vascular stents is evaluated through long and expensive trials. Pre-clinical studies, where stents are tested in animal models, further contribute to the expense of bringing new devices to market. The purpose of pre-clinical studies is to assess stent induced thrombus formation, inflammatory response, neointimal hyperplasia, and late thromobosis. Whether the trial is pre-clinical or clinical, the biologic responses to stents are, in large part, due to the surface and structural characteristics of the stent being tested.
Stent Induced Smooth Muscle Cell Proliferation: An In Vitro System for Rapid Evaluation
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Berry, JL, & Yazdani, SK. "Stent Induced Smooth Muscle Cell Proliferation: An In Vitro System for Rapid Evaluation." Proceedings of the ASME 2007 Summer Bioengineering Conference. ASME 2007 Summer Bioengineering Conference. Keystone, Colorado, USA. June 20–24, 2007. pp. 767-768. ASME. https://doi.org/10.1115/SBC2007-176798
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