Recent experiments strongly suggest that osteocytes, the most numerous bone cells, play much more active roles in bone adaptation and metabolism . These multifunctioning cells are found to detect external mechanical stimuli, and to release soluable agents that modulate the functioning of other cell types [1, 2]. Solute transport around osteocytes through the bone lacunar-canalicular system (LCS), especially via load-induced convection, is critical for osteocyte viability and proper functioning. However, despite of significant advance in elucidating the LCS microstructure, permeability, and the molecular sieving properties [3–5], the fundamental mechanisms of solute transport around osteocytes still remain poorly understood, and solute flows have not been quantified in vivo.
- Bioengineering Division
Modeling Fluorescence Recovery After Photobleaching in Cyclically Loaded Bone: Potential Application in Quantitatively Measuring Load-Induced Solute Flows
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Zhou, X, Novotny, JE, & Wang, L. "Modeling Fluorescence Recovery After Photobleaching in Cyclically Loaded Bone: Potential Application in Quantitatively Measuring Load-Induced Solute Flows." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 567-568. ASME. https://doi.org/10.1115/SBC2008-193018
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