The stabilization of proteins is a priority for several important fields, most notably the pharmaceutical industry. Protein-based therapeutic drugs have demonstrated significant efficacy in controlling and curing disease. Unlike traditional small molecule-based drug therapies, a major hurdle in the development of protein drugs is the challenge of maintaining the protein in the folded state throughout processing and also during storage at the end point-of-use. When a protein is taken from its native environment, it is often unstable and unfolds. Because the protein’s 3-dimensional structure is responsible for its functional activity, much work has been dedicated to finding excipients that will stabilize proteins outside of their native environment.
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Biocompatible Ionic Liquids: A New Approach for Stabilizing Proteins in Liquid Formulation
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Kemp, R, Fraser, K, Fujita, K, MacFarlane, D, & Elliott, G. "Biocompatible Ionic Liquids: A New Approach for Stabilizing Proteins in Liquid Formulation." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 947-948. ASME. https://doi.org/10.1115/SBC2008-192986
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