One of the most significant limitations of percutaneous coronary intervention using stents is the growth of tissue within the stent, leading to re-occlusion of the target vessel. There is a wide range of stents available, and stent designs differ in their efficacy . Stent parameters such as stent length, strut configuration, diameter and expansion method have been shown to influence the amount of restenosis provoked . Despite many generations of coronary stents — and the advent of drug elution — up to 10% of percutaneous coronary interventions require revision, climbing to 50% in some high risk lesions .
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Injury Driven Biological Model of Restenotic Lesion Development Predicts the Effects of Stent Geometry on Restenosis
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Boyle, CJ, Lally, C, & Prendergast, PJ. "Injury Driven Biological Model of Restenotic Lesion Development Predicts the Effects of Stent Geometry on Restenosis." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1055-1056. ASME. https://doi.org/10.1115/SBC2009-206342
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