Given mounting evidence that mechanical force is a critical parameter in the normal development and remodeling of load-bearing tissue, there is a critical need for a new class of bioreactors which can apply controlled loads/strains to tissues or engineered constructs while permitting high-powered optical accessibility. We have developed a novel bioreactor which can be mounted onto the stage of an inverted microscope which permits direct 600× observation of a perfused specimen while the specimen is held in either load or strain control. Further, the chamber has been designed to minimize free volume to reduce the cost of reagents.
- Bioengineering Division
Design of Optically Accessible, Ultra Low-Volume, Tissue Loading Bioreactor
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Patenaude, JA, Desjarlais, A, Kornfeld, J, Lee, M, McGrath, M, Perry, J, & Ruberti, JW. "Design of Optically Accessible, Ultra Low-Volume, Tissue Loading Bioreactor." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1195-1196. ASME. https://doi.org/10.1115/SBC2009-206675
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