Elastin provides reversible extensibility and stores energy during the cardiac cycle in large blood vessels. It is only present in vertebrate animals with a closed circulatory system and high, pulsatile blood pressures. Elastin is crucial for proper cardiac function in vertebrates, as mice lacking elastin (eln-/-) die soon after birth with cardiovascular abnormalities including long, tortuous, stenotic, stiff arteries and high left ventricular (LV) pressure with low cardiac output [1, 2].
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Developmental Cardiovascular Remodeling Associated With Reduced Elastin Levels in Mice Occurs After Embryonic Day 18
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Wagenseil, JE, Ciliberto, CH, Knutsen, RH, Levy, MA, Kovacs, A, & Mecham, RP. "Developmental Cardiovascular Remodeling Associated With Reduced Elastin Levels in Mice Occurs After Embryonic Day 18." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 1299-1300. ASME. https://doi.org/10.1115/SBC2009-204476
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