Prolonged mechanical loading of soft tissues, as present when individuals are bedridden or wheelchair-bound, can lead to degeneration of skeletal muscle tissue. This can result in a condition termed pressure-related deep tissue injury (DTI), a severe kind of pressure ulcer that initiates in deep tissue layers, e.g. skeletal muscle, near bony prominences and progresses towards the skin. Complications associated with DTI include sepsis, renal failure, and myocardial infarction. Damage pathways leading to DTI involve ischemia, ischemia-reperfusion injury, impaired lymphatic drainage, and sustained tissue deformation. Recently, the role of tissue deformation in the onset of skeletal muscle damage was established by combining animal experiments with finite element (FE) modeling [1]. After 2 hours of continuous loading, a clear correlation between maximum shear strain and damage was found.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Effect of Continuous and Intermittent Mechanical Loading on the Development of Skeletal Muscle Damage - A Combined Experimental/Numerical Approach
Sandra Loerakker,
Sandra Loerakker
Eindhoven University of Technology, Eindhoven, The Netherlands
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Anke Stekelenburg,
Anke Stekelenburg
Eindhoven University of Technology, Eindhoven, The Netherlands
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Gustav J. Strijkers,
Gustav J. Strijkers
Eindhoven University of Technology, Eindhoven, The Netherlands
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Klaas Nicolay,
Klaas Nicolay
Eindhoven University of Technology, Eindhoven, The Netherlands
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Dan L. Bader,
Dan L. Bader
Eindhoven University of Technology, Eindhoven, The Netherlands
University of London, London, UK
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Frank P. T. Baaijens,
Frank P. T. Baaijens
Eindhoven University of Technology, Eindhoven, The Netherlands
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Cees W. J. Oomens
Cees W. J. Oomens
Eindhoven University of Technology, Eindhoven, The Netherlands
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Sandra Loerakker
Eindhoven University of Technology, Eindhoven, The Netherlands
Anke Stekelenburg
Eindhoven University of Technology, Eindhoven, The Netherlands
Gustav J. Strijkers
Eindhoven University of Technology, Eindhoven, The Netherlands
Klaas Nicolay
Eindhoven University of Technology, Eindhoven, The Netherlands
Dan L. Bader
Eindhoven University of Technology, Eindhoven, The Netherlands
University of London, London, UK
Frank P. T. Baaijens
Eindhoven University of Technology, Eindhoven, The Netherlands
Cees W. J. Oomens
Eindhoven University of Technology, Eindhoven, The Netherlands
Paper No:
SBC2009-206354, pp. 341-342; 2 pages
Published Online:
July 19, 2013
Citation
Loerakker, S, Stekelenburg, A, Strijkers, GJ, Nicolay, K, Bader, DL, Baaijens, FPT, & Oomens, CWJ. "Effect of Continuous and Intermittent Mechanical Loading on the Development of Skeletal Muscle Damage - A Combined Experimental/Numerical Approach." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 341-342. ASME. https://doi.org/10.1115/SBC2009-206354
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