Since the healing capacity of articular cartilage is limited, it is important to develop cell-based therapies for the repair of cartilage. Although synthetic or animal-derived scaffolds are frequently used for effective cell delivery long-term safety and efficiency of such scaffolds still remain unclear. We have been developing a new tissue engineering technique for cartilage repair using a scaffold-free tissue engineered construct (TEC) bio-synthesized from synovium-derived mesenchymal stem cells (MSCs) . As the TEC specimen is composed of cells with their native extracellular matrix, we believe that it is free from concern regarding long term immunological effects. Fujie et al. found in a micro indentation test using an atomic force microscope (AFM) that the immature porcine cartilage-like tissue repaired with TEC exhibited lower stiffness as compared with normal cartilage in immature porcine femur , although the macro-scale stiffness of the repaired tissue was almost same as that of the normal cartilage . In the present study, we investigated the macro and micro-compressive properties of mature porcine cartilage-like tissue repaired with TEC.
- Bioengineering Division
Surface and Bulk Stiffness of the Mature Porcine Cartilage-Like Tissue Repaired With a Scaffold-Free, Stem Cell-Based Tissue Engineered Construct (TEC)
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Nansai, R, Ogata, M, Takeda, J, Ando, W, Nakamura, N, & Fujie, H. "Surface and Bulk Stiffness of the Mature Porcine Cartilage-Like Tissue Repaired With a Scaffold-Free, Stem Cell-Based Tissue Engineered Construct (TEC)." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 735-736. ASME. https://doi.org/10.1115/SBC2009-204404
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