Otitis Media (OM) is the most commonly diagnosed childhood illness and has health care related cost of four billion dollars annually. [1] The onset of OM has been directly related to Eustachian Tube (ET) dysfunction. The ET has three main physiological functions, and when these functions are compromised, middle ear (ME) disorders arise. It is also known that specific populations of patients, such as those with cranio-facial abnormalities, such as a cleft palate, have a 100% onset rate of OM. Even though ET dysfunction has been related to OM, the underlying reasons for ET dysfunction in certain populations remains unknown. To gain an understanding of this system, we use fully coupled fluid-structure interaction (FSI) models of the ET based on geometries reconstructed from histological images. Using these models in systematic parameter variation studies allows us to identify which parameters of the ET can cause dysfunction. Using healthy adult subjects as a model for a well-functioning ET, we determined ET function to be sensitive to changes in TVP muscle force.

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