Traumatic impaction is known to cause acute cell death and macroscopic damage to cartilage and menisci in vitro1,2,3. It is understood that damage to the menisci can lead to chronic problems associated with excessive cartilage wear and the eventual onset of osteoarthritis (OA)4. Additionally, cartilage fissuring, subchondral bone bruising, and chondrocyte death are also believed to lead to the rapid progression of joint degeneration5. Such injuries, along with posterolateral meniscal tearing, are often observed after traumatic impaction and anterior cruciate ligament (ACL) rupture6–9. Therefore, understanding how the menisci and cartilage respond acutely to impaction may help guide future therapies following traumatic knee injury in order to prevent the development of OA.

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