Vascular smooth muscle cells (VSM) modulate cardiac output, maintain vascular pressure, and regulate blood flow via contraction. This contraction is generated by a mechanochemical interaction of actin-myosin cross-bridges within each cell and is governed by the biochemical and mechanical state of the cell . When this state is disturbed, VSM cells can respond with excessive constriction (which can lead to hypertension) or weakened residual stresses (which can result in aortic aneurysms); both of which are considered to be symptoms of cardiovascular diseases . Furthermore, disruption in the state of VSM cells can cause their migration into the intimal layer of the artery, which is a precursor to atherosclerosis.
- Bioengineering Division
A Multi-Physics Finite Element Model of the Traction Forces in a Three-Dimensional Smooth Muscle Cell
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Rodriguez, ML, Han, SJ, & Sniadecki, NJ. "A Multi-Physics Finite Element Model of the Traction Forces in a Three-Dimensional Smooth Muscle Cell." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 963-964. ASME. https://doi.org/10.1115/SBC2011-53944
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