Measurements of local nanomechanical properties of living cells recently have become extremely important for the cellular biology and biomechanics communities . The measurement of progressive variations in viscoelastic properties of living cells in their native physiological liquid environments can provide significant insight to the mechanistic processes underpinning morphogenesis, mechano-transduction, motility, metastasis, aging, etc. Atomic Force Microscopy (AFM) based biomechanical assays have the unique advantage of resolving/mapping spatially the local nanomechanical properties over the cell surface. However current methods using standard force-volume, force displacement curves [2–3] are very low resolution and low speed making them completely incompatible for biomechanical assays of living cells.
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Quantitative Mapping of Local Mechanical Properties of Living Cells at Near-Physiological Conditions Using Multi-Harmonic Atomic Force Microscopy
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Cartagena, A, Wang, W, Geahlen, RL, & Raman, A. "Quantitative Mapping of Local Mechanical Properties of Living Cells at Near-Physiological Conditions Using Multi-Harmonic Atomic Force Microscopy." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 523-524. ASME. https://doi.org/10.1115/SBC2012-80837
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