Previously, microbubbles have been studied for a number of different medical applications including ultrasound imaging contrast and drug delivery . Microbubbles are comprised of a gas enclosed in a lipid shell. Recent research has shown that the inclusion of microbubbles in tissue engineered cartilage constructs has been shown to enhance mechanical and biochemical growth [2,3]. This modification of the tissue engineering scaffold by incorporation of gas-filled microbubbles has been shown to homogenize depth-dependent mechanical properties (Fig. 1) , which, in standard constructs, resembles a “U-shaped” strain profile with the stiffest regions on the edges surrounding a soft center . In addition, these microbubble containing constructs are described by a higher partition coefficient than standard constructs, indicating increased solute transport . These results led us to propose the hypothesis that the incorporation of microbubbles: a) increases nutrient transport upon microbubble dissolution, b) creates fluid-filled pores upon gas efflux and subsequent influx of culture media . In this study, the aforementioned hypothesis is interrogated through analysis of local solute diffusivity.
- Bioengineering Division
Effect of Microbubble Incorporation on Local Solute Transport in Tissue Engineered Cartilage Constructs
Nover, AB, Durney, KM, Sirsi, SR, Ateshian, GA, Borden, MA, Lima, EG, & Hung, CT. "Effect of Microbubble Incorporation on Local Solute Transport in Tissue Engineered Cartilage Constructs." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 627-628. ASME. https://doi.org/10.1115/SBC2012-80608
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