Microscale mechanical properties of soft biomaterials, such as heart valves, are of interest to researchers studying the effects of matrix mechanical properties on cell function. Measurements at the microscale, on the order of 1–500 μm, are representative of the mechanical properties experienced by the cells in their environment (1). In contrast, other methods like conventional tensile/compression testing and atomic force microscopy provide macroscale and nanoscale properties, respectively, that do not reflect the local micromechanical environment at the cellular scale.
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A Novel Device for the Microindentation of Soft Biomaterials With Application to Aortic Valve Leaflets
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Doyle, MG, Chehade, M, & Simmons, CA. "A Novel Device for the Microindentation of Soft Biomaterials With Application to Aortic Valve Leaflets." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT04A023. ASME. https://doi.org/10.1115/SBC2013-14733
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