Chronic deep venous insufficiency (CDVI) is a disease caused by incompetent venous valves in the deep veins which result in venous reflux and pooling of blood in the lower extremities. Symptoms include edema, skin changes, and ulceration. It is estimated that over six million people in the United States are affected by this disease and symptoms can be recurring, leading to an underestimation of the prevalence. The current treatments of CDVI are management techniques to encourage blood flow and oxygen transport, including compression, elevation, and exercise; strategies to repair or replace the incompetent valves are lacking.
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A Treatment for Chronic Deep Venous Insufficiency Utilizing Induced Pluripotent Stem Cell Derived Endothelial Cells
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Jones, CM, Mirza, KL, Blakley, BJ, Pavcnik, D, & Hinds, MT. "A Treatment for Chronic Deep Venous Insufficiency Utilizing Induced Pluripotent Stem Cell Derived Endothelial Cells." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT12A005. ASME. https://doi.org/10.1115/SBC2013-14628
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