A viable tissue engineered heart valve (TEHV) replacement would eliminate disadvantages associated with currently available prosthetics, such as thrombosis and increased risk of valve calcification. Viable TEHVs also are promising in that they can actively remodel and grow, as they would be populated with cells similar to native valves. Valvular interstitial cells (VICs) organize and maintain the complex structure of valves throughout the life of an organism. Considerable effort has been made towards identifying a source of VICs for next generation prosthetic heart valves. Despite this effort, the mechanisms by which VICs are produced in development, via endocardial epithethelial-to-mesenchymal transformation (EMT), are not fully understood. EMT is the critical first step in the formation of heart valve leaflets in utero, and thus a thorough understanding of the biomechanical and signaling environments that regulate EMT could lead to advancements in viable TEHVs.
- Bioengineering Division
Collagen-Hyaluronic Acid Hydrogels Provide Enhanced EMT of Endocardial Cells
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Sewell-Loftin, MK, DeLaughter, DM, Barnett, JV, & Merryman, WD. "Collagen-Hyaluronic Acid Hydrogels Provide Enhanced EMT of Endocardial Cells." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments. Sunriver, Oregon, USA. June 26–29, 2013. V01AT15A002. ASME. https://doi.org/10.1115/SBC2013-14204
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