Blood-borne substances such as oxygen, nutrients, drugs and particles arrive at targeted tissues through a multi-step process that begins with convection along the blood vessels and then movement from the blood vessels to the surrounding tissues by convection through the cellular interstices or molecular diffusion. Interstitial convection may be important in the margins of tumors where highly permeable blood vessels encounter high transmural pressures, but otherwise, transport from the blood vessels to the tissues progresses primarily by diffusion.

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