The menisci are semi-lunar wedge-shaped structures that play critical roles in load distribution, shock absorption, and joint congruity in the knee. Meniscal tears are common knee injuries that subsequently lead to degenerative arthritis, attributed primarily to the changes in stress distribution in the knee. In such cases there is a need to protect the articular cartilage by either repairing or replacing the menisci. While traditionally, meniscal replacement involves implantation of allografts, problems related to availability, size matching, cost and risk of disease transmission limit their use. Another potential treatment option is that of biodegradable scaffolds, which are based principally on tissue engineering concepts. The variability in body response to biodegradable implants and the quality of the tissue formed still pose a problem in this respect, particularly in light of the intense loading conditions in the knee. Moreover, the aforementioned repair and regenerative approaches are generally limited to younger patients. Therefore, the goal of this study was, to develop a synthetic meniscal implant which can replace the injured meniscus, restore its function, and relieve pain.
- Bioengineering Division
Biomechanical Versus Clinical Considerations in the Development of a Novel Polycarbonate-Urethane Meniscus Implant
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Elsner, JJ, Condello, V, Zorzi, C, Arbel, R, Hershman, E, Guilak, F, & Linder-Ganz, E. "Biomechanical Versus Clinical Considerations in the Development of a Novel Polycarbonate-Urethane Meniscus Implant." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT34A003. ASME. https://doi.org/10.1115/SBC2013-14422
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