Cryopreservation of cells and tissues is critical to long term storage and off the shelf availability of biomaterials for a variety of disciplines. Typical cryopreservation protocols aim to remove intracellular water by exposing the sample to a cryoprotective agent (CPA) to create an osmotic pressure gradient. While CPAs are useful in preventing cell damage due to intracellular ice formation, the dehydration process can induce harmful osmotic shock.
- Bioengineering Division
Distributions During Cryoprotective Agent Loading in a Microchannel
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Scherr, TF, Pursley, S, Monroe, WT, & Nandakumar, K. "Distributions During Cryoprotective Agent Loading in a Microchannel." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT36A005. ASME. https://doi.org/10.1115/SBC2013-14691
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