Magnetic nanoparticles are currently under intense investigation as a heating strategy for hyperthermia cancer treatment because they are promising as a means to target the heating specifically to the tumor.[1–4] Currently, our ability to create practical and useful numerical models in dimensional spaces similar to ordinary small tumors is severely hampered by the multiple orders of magnitude of the relative scales: nm to mm. Consequently, the preponderance of literature on the topic describes experimental studies only. Detailed individual nanoparticle model spaces with moderate dimensions up to mm would be nearly intractably computationally intensive, requiring peta-scale computing resources. It would advance the state of the art to be able to apply practical computing machinery to analyze realistic medium scale in vivo systems. Such a tool could be reasonably applied in experimental analysis, and potentially in treatment planning and assessment.
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Simplified Medium Scale FEM Numerical Models of Magnetic Nanoparticle Heating: Study of Thermal Boundary Condition Effects
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Pearce, J. "Simplified Medium Scale FEM Numerical Models of Magnetic Nanoparticle Heating: Study of Thermal Boundary Condition Effects." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT42A001. ASME. https://doi.org/10.1115/SBC2013-14172
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