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Mechanotransduction and Sub-Cellular Biophysics
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Proceedings Papers

Cell Shape Dictates Differential Sensitivity of Subcellular Contractile Forces in Response to Directional Substrate Stretch

Yue Shao, Jennifer M. Mann, Jianping Fu
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT35A001, June 26–29, 2013
Paper No: SBC2013-14225
https://doi.org/10.1115/SBC2013-14225
View Paper titled, Cell Shape Dictates Differential Sensitivity of Subcellular Contractile Forces in Response to Directional Substrate Stretch
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Topics: Adhesion, Feedback, Geometry, Shapes, Stiffness
Proceedings Papers

Visualizing Chondrocyte Mechanotransduction in 3D

Qiaoqiao Wan, Eunhye Cho, Seungman Park, Bumsoo Han, Hiroki Yokota, Sungsoo Na
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT35A002, June 26–29, 2013
Paper No: SBC2013-14484
https://doi.org/10.1115/SBC2013-14484
View Paper titled, Visualizing Chondrocyte Mechanotransduction in 3D
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Topics: Chondrocytes, Cartilage, Maintenance, Stress, Adhesion, Biosensors, Energy transformation, Enzymes, Fluorescence, Linkages
Proceedings Papers

The Viscoelastic Properties of Mouse Embryonic Salivary Glands

Ryan A. Koppes, Andrew K. Mason, Sarah B. Peters, Shayoni Ray, Melinda Larsen, David T. Corr
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT35A003, June 26–29, 2013
Paper No: SBC2013-14600
https://doi.org/10.1115/SBC2013-14600
View Paper titled, The Viscoelastic Properties of Mouse Embryonic Salivary Glands
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Topics: Biological tissues, Cancer, Diseases, Maintenance, Tension, Viscoelasticity
Proceedings Papers

Effects of Bisphosphonate on Long-Term Culture of Cartilage Allografts

Yilu Zhou, Lauren Resutek, Liyun Wang, X. Lucas Lu
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT35A004, June 26–29, 2013
Paper No: SBC2013-14635
https://doi.org/10.1115/SBC2013-14635
View Paper titled, Effects of Bisphosphonate on Long-Term Culture of Cartilage Allografts
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Topics: Cartilage, Chondrocytes, Biomechanics, Biomedicine, Bone, Diseases, Food and Drug Administration, Frequency-domain analysis, Osteoarthritis
Proceedings Papers

Analysis of the Active Response of Cells to Cyclic Loading Using a Modified AFM System

P. Weafer, N. Reynolds, W. Ronan, E. Dowling, S. Jarvis, P. McGarry
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT35A005, June 26–29, 2013
Paper No: SBC2013-14793
https://doi.org/10.1115/SBC2013-14793
View Paper titled, Analysis of the Active Response of Cells to Cyclic Loading Using a Modified AFM System
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Topics: Atomic force microscopy, Deformation, Biological tissues, Maintenance, Osteoblasts, Tension, Testing
Proceedings Papers

The Direction of Cyclic Stretch-Induced Cell and Stress Fiber Alignment Depends on Matrix Rigidity

Abhishek Tondon, Roland Kaunas
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT35A006, June 26–29, 2013
Paper No: SBC2013-14794
https://doi.org/10.1115/SBC2013-14794
View Paper titled, The Direction of Cyclic Stretch-Induced Cell and Stress Fiber Alignment Depends on Matrix Rigidity
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Topics: Fibers, Stiffness, Stress, Tension, Chain, Modeling, Sensors
Proceedings Papers

Adhesive Signature-Based, Label-Free Isolation of Human Pluripotent Stem Cells

Ankur Singh, Shalu Suri, Ted T. Lee, Jamie M. Chilton, Steve L. Stice, Hang Lu, Todd C. McDevitt, Andrés J. Garcia
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 313-314, June 20–23, 2012
Paper No: SBC2012-80044
https://doi.org/10.1115/SBC2012-80044
View Paper titled, Adhesive Signature-Based, Label-Free Isolation of Human Pluripotent Stem Cells
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Topics: Adhesives, Stem cells, Fibroblasts, Contamination, Diseases
Proceedings Papers

Dynamic Mechanical Properties Control Adult Stem Cell Fate

Murat Guvendiren, Jason A. Burdick
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 315-316, June 20–23, 2012
Paper No: SBC2012-80062
https://doi.org/10.1115/SBC2012-80062
View Paper titled, Dynamic Mechanical Properties Control Adult Stem Cell Fate
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Topics: Mechanical properties, Stem cells, Elasticity, Biological tissues, Biomedicine, Cancer, Hydrogels, Polymerization, Polymers, Stiffness
Proceedings Papers

Investigation of Mechanoresponsive Behaviors of Human Embryonic Stem Cells Using Microfabricated Elastomeric Post Arrays

Yubing Sun, Luis G. Villa-Diaz, Raymond H. W. Lam, Weiqiang Chen, Paul H. Krebsbach, Jianping Fu
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 317-318, June 20–23, 2012
Paper No: SBC2012-80269
https://doi.org/10.1115/SBC2012-80269
View Paper titled, Investigation of Mechanoresponsive Behaviors of Human Embryonic Stem Cells Using Microfabricated Elastomeric Post Arrays
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Topics: Stem cells, Signals
Proceedings Papers

Cytoskeletal Fluidization and Resolidification are Required for Reorientation of Endothelial Cells

Ramaswamy Krishnan, Elizabeth Peruski Canovic, Andreea L. Iordan, Athanassios P. Pirentis, Kavitha Rajendran, Greeshma Manomohan, Michael L. Smith, James P. Butler, Jeffrey J. Fredberg, Dimitrije Stamenović
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 319-320, June 20–23, 2012
Paper No: SBC2012-80431
https://doi.org/10.1115/SBC2012-80431
View Paper titled, Cytoskeletal Fluidization and Resolidification are Required for Reorientation of Endothelial Cells
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Topics: Endothelial cells, Fluidization
Proceedings Papers

Applied Osmotic Loading for Promoting Development of Engineered Cartilage

Sonal R. Sampat, Drew A. Robinson, George P. Ackerman, Matthew V. Dermksian, Gerard A. Ateshian, Clark T. Hung
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 321-322, June 20–23, 2012
Paper No: SBC2012-80449
https://doi.org/10.1115/SBC2012-80449
View Paper titled, Applied Osmotic Loading for Promoting Development of Engineered Cartilage
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Topics: Cartilage, Chondrocytes, Biological tissues, Maintenance, Agar, Damage, Deformation, Hydrogels, Mechanical properties, Patient treatment
Proceedings Papers

Dynamic Tensile Loading and Altered Cell Contractility Modulate Nuclear Deformation and Cytoskeletal Connectivity

Tristan P. Driscoll, Su-Jin Heo, Robert L. Mauck
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 323-324, June 20–23, 2012
Paper No: SBC2012-80550
https://doi.org/10.1115/SBC2012-80550
View Paper titled, Dynamic Tensile Loading and Altered Cell Contractility Modulate Nuclear Deformation and Cytoskeletal Connectivity
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Topics: Deformation, Dynamic testing (Materials), Membranes, Orthopedics, Proteins, Stem cells, Stress, Tissue engineering
Proceedings Papers

Dynamic Tensile Loading Activates TGF and BMP Signaling in Mesenchymal Stem Cells on Aligned Nanofibrous Scaffolds

Su-Jin Heo, Tristan P. Driscoll, Robert L. Mauck
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 325-326, June 20–23, 2012
Paper No: SBC2012-80706
https://doi.org/10.1115/SBC2012-80706
View Paper titled, Dynamic Tensile Loading Activates TGF and BMP Signaling in Mesenchymal Stem Cells on Aligned Nanofibrous Scaffolds
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Topics: Stem cells, Tissue engineering, Bone, Orthopedics, Proteins, Stiffness, Tension
Proceedings Papers

Dependence of Cyclic Stretch-Induced Stress Fiber Reorientation on Stretch Waveform

Abhishek Tondon, Hui-Ju Hsu, Roland Kaunas
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 327-328, June 20–23, 2012
Paper No: SBC2012-80778
https://doi.org/10.1115/SBC2012-80778
View Paper titled, Dependence of Cyclic Stretch-Induced Stress Fiber Reorientation on Stretch Waveform
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Topics: Fibers, Stress, Equilibrium (Physics), Cardiac cycle, Endothelial cells, Tension
Proceedings Papers

Calcium Signaling of Chondrocytes Under Osmotic Stress and Mechanical Stimulation

Wen Li, Miri Park, Catherine Kirn-Safran, Liyun Wang, X. Lucas Lu
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 329-330, June 20–23, 2012
Paper No: SBC2012-80811
https://doi.org/10.1115/SBC2012-80811
View Paper titled, Calcium Signaling of Chondrocytes Under Osmotic Stress and Mechanical Stimulation
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Topics: Chondrocytes, Stress, Cartilage, Oscillations, Primary cells, Signals, Transients (Dynamics)
Proceedings Papers

Integrin-Focal Adhesion Coupling and Substrate Stiffness Affect Smooth Muscle Alpha Actin Expression in Fibroblasts

Alison K. Schroer, W. David Merryman
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 331-332, June 20–23, 2012
Paper No: SBC2012-80887
https://doi.org/10.1115/SBC2012-80887
View Paper titled, Integrin-Focal Adhesion Coupling and Substrate Stiffness Affect Smooth Muscle Alpha Actin Expression in Fibroblasts
Open the PDF for Integrin-Focal Adhesion Coupling and Substrate Stiffness Affect Smooth Muscle Alpha Actin Expression in Fibroblasts in another window
Topics: Adhesion, Fibroblasts, Muscle, Stiffness, Biological tissues, Diseases, Stress, Atherosclerosis, Fibers, Lung
Proceedings Papers

Mechanical Communication Between Cardiac Cell Leads to Synchrony in Beating

Xin Tang, Piyush Bajaj, Rashid Bashir, Taher Saif
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 333-334, June 20–23, 2012
Paper No: SBC2012-80937
https://doi.org/10.1115/SBC2012-80937
View Paper titled, Mechanical Communication Between Cardiac Cell Leads to Synchrony in Beating
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Topics: Dynamics (Mechanics), Elastic moduli, Stiffness