To investigate the effect of junction strands on microvessel permeability, we extend the previous analytical model developed by Fu et al. (1994, J. Biomech. Eng., 116, pp. 502–513), for the interendothelial cleft to include multiple junction strands in the cleft and an interface between the surface glycocalyx layer and the cleft entrance. Based on the electron microscopic observations by Adamson et al. (1998, Am. J. Physiol., 274(43), pp. H1885–H1894), that elevation of intracellular cAMP levels would increase number of tight junction strands, this two-junction-strand and two-pore model can successfully account for the experimental data for the decreased permeability to water, small and intermediate-sized solutes by cAMP.
A Model for the Modulation of Microvessel Permeability by Junction Strands
Contributed by the Bioengineering Division for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received by the Bioengineering Division November 13, 2002; revision received February 18, 2003. Associate Editor: C. Dong.
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Fu, B. M., and Chen, B. (October 9, 2003). "A Model for the Modulation of Microvessel Permeability by Junction Strands ." ASME. J Biomech Eng. October 2003; 125(5): 620–627. https://doi.org/10.1115/1.1611514
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