As part of an ongoing effort to study the continuum mechanics effects associated with cryopreservation, the current report focuses on the prediction of fracture formation in cryoprotective agents. Fractures had been previously observed in samples of the cryoprotective agent cocktail DP6, contained in a standard glass vial, and subjected to various cooling rates. These experimental observations were obtained by means of a cryomacroscope, which has been recently presented by the current research team. High and low cooling rates were found to produce very distinct patterns of cracking. The current study seeks to explain the observed patterns on the basis of stresses predicted from finite element analysis, which relies on a simple viscoelastic constitutive model and on estimates of the critical stress for cracking. The current study demonstrates that the stress, which results in instantaneous fracture at low cooling rates, is consistent with the stress to initiate fracture at high cooling rate. This consistency supports the credibility of the proposed constitutive model and analysis, and the unified criterion for fracturing, that is, a critical stress threshold.
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April 2008
Research Papers
Continuum Mechanics Analysis of Fracture Progression in the Vitrified Cryoprotective Agent DP6
Paul S. Steif,
Paul S. Steif
Biothermal Technology Laboratory, Department of Mechanical Engineering,
Carnegie Mellon University
, 5000 Forbes Avenue, Pittsburgh, PA 15237
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Matthew C. Palastro,
Matthew C. Palastro
Biothermal Technology Laboratory, Department of Mechanical Engineering,
Carnegie Mellon University
, 5000 Forbes Avenue, Pittsburgh, PA 15237
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Yoed Rabin
Yoed Rabin
Biothermal Technology Laboratory, Department of Mechanical Engineering,
e-mail: rabin@cmu.edu
Carnegie Mellon University
, 5000 Forbes Avenue, Pittsburgh, PA 15237
Search for other works by this author on:
Paul S. Steif
Biothermal Technology Laboratory, Department of Mechanical Engineering,
Carnegie Mellon University
, 5000 Forbes Avenue, Pittsburgh, PA 15237
Matthew C. Palastro
Biothermal Technology Laboratory, Department of Mechanical Engineering,
Carnegie Mellon University
, 5000 Forbes Avenue, Pittsburgh, PA 15237
Yoed Rabin
Biothermal Technology Laboratory, Department of Mechanical Engineering,
Carnegie Mellon University
, 5000 Forbes Avenue, Pittsburgh, PA 15237e-mail: rabin@cmu.edu
J Biomech Eng. Apr 2008, 130(2): 021006 (7 pages)
Published Online: March 28, 2008
Article history
Received:
February 20, 2006
Revised:
August 3, 2007
Published:
March 28, 2008
Citation
Steif, P. S., Palastro, M. C., and Rabin, Y. (March 28, 2008). "Continuum Mechanics Analysis of Fracture Progression in the Vitrified Cryoprotective Agent DP6." ASME. J Biomech Eng. April 2008; 130(2): 021006. https://doi.org/10.1115/1.2898716
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