Laser direct-write technology such as modified laser-induced forward transfer (LIFT) is emerging as a revolutionary technology for biological construct fabrication. While many modified LIFT-based cell direct writing successes have been achieved, possible process-induced cell injury and death is still a big hurdle for modified LIFT-based cell direct writing to be a viable technology. The objective of this study is to propose metallic foil-assisted LIFT using a four-layer structure to achieve better droplet size control and increase cell viability in direct writing of human colon cancer cells (HT-29). The proposed four layers include a quartz disk, a sacrificial and adhesive layer, a metallic foil, and a cell suspension layer. The bubble formation-induced stress wave is responsible for droplet formation. It is found that the proposed metallic foil-assisted LIFT approach is an effective cell direct-write technology and provides better printing resolution and high post-transfer cell viability when compared with other conventional modified LIFT technologies such as matrix-assisted pulsed-laser evaporation direct-write; at the same time, the possible contamination from the laser energy absorbing material is minimized using a metallic foil.
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e-mail: yongh@clemson.edu
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February 2011
Design Innovations
Metallic Foil-Assisted Laser Cell Printing
Yafu Lin,
Yafu Lin
Department of Mechanical Engineering,
Clemson University
, Clemson, SC 29634
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Yong Huang,
Yong Huang
Department of Mechanical Engineering,
e-mail: yongh@clemson.edu
Clemson University
, Clemson, SC 29634
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Douglas B. Chrisey
Douglas B. Chrisey
Department of Materials Science and Engineering, and Biomedical Engineering,
Rensselaer Polytechnic Institute
, Troy, NY 12180
Search for other works by this author on:
Yafu Lin
Department of Mechanical Engineering,
Clemson University
, Clemson, SC 29634
Yong Huang
Department of Mechanical Engineering,
Clemson University
, Clemson, SC 29634e-mail: yongh@clemson.edu
Douglas B. Chrisey
Department of Materials Science and Engineering, and Biomedical Engineering,
Rensselaer Polytechnic Institute
, Troy, NY 12180J Biomech Eng. Feb 2011, 133(2): 025001 (5 pages)
Published Online: January 5, 2011
Article history
Received:
September 17, 2010
Revised:
November 16, 2010
Posted:
November 29, 2010
Published:
January 5, 2011
Online:
January 5, 2011
Citation
Lin, Y., Huang, Y., and Chrisey, D. B. (January 5, 2011). "Metallic Foil-Assisted Laser Cell Printing." ASME. J Biomech Eng. February 2011; 133(2): 025001. https://doi.org/10.1115/1.4003132
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