... Corresponding author. e-mail:  avril@emse.fr 22 02 2021 29 11 2021 21 02 2022 cell biomechanics ascendant thoracic aortic aneurysm (ATAA) mechanotransduction smooth muscle cells (SMC) fluorescent microscopy (FM) atomic force microscopy (AFM) nanoindentation European...

... and biomechanical forces influence disease growth. Wall shear stress (WSS) affects coronary artery atherosclerosis by inducing endothelial cell mechanotransduction and by controlling the near-wall transport processes involved in atherosclerosis. Each of these processes is controlled by WSS differently and therefore...

...” by mural cells in vivo, which is thought to be important in aortic diseases related to cellular mechanotransduction [ 28 ]. Thus, we assert that axially isometric plus isobaric testing is necessarily superior given both the extra data available for analysis and its greater relevance to in vivo...

... mechanics fibroblast mechanotransduction mechanical environment Cell activity is controlled by a complex set of spatially and temporally varying environmental cues. Recently, it has been demonstrated that in addition to soluble biochemical factors, the properties of the surrounding extracellular...

...-like phenotype. Adapala et al. [ 32 ] illustrated a critical role for transient receptor potential vallinoid type 4 (TRPV4) mechanotransductive ion channels in the propagation of TGF-β-derived induction of the myofibroblast phenotype. These TRPV4 channels become activated in the presence of TGF-β...

... the physiological implications of tissue loading in all conditions, a review of mechanotransduction pathways in the cartilage, ligament and bone is also presented ranging from the tissue-level scale to cellular modifications. With this context, experimental studies are summarized as they relate to the most common...

... engineering finite element model cartilage tissue engineering mechanical stimulation hydrogel poly(ethylene glycol) mechanotransduction chondrocyte Cartilage cells are sensitive to their mechanical environment and react directly to mechanical stimulation. The coupled mechanical...

... and FGF-2 in 3D culture. In conclusion, gene expression is different between 2D and 3D osteoblast cultures under static conditions. Additionally, osteoblasts respond to shear stress differently in 2D and 3D cultures. Our results highlight the importance of 3D mechanotransduction studies for bone tissue...

... conditioning mechanotransduction volumetric growth There is a great unmet clinical need to develop small diameter tissue engineered blood vessels (TEBVs) with low thrombogenicity and immune response, suitable mechanical properties, and a capacity to adapt to their environment ( 1 2 3 ). Since...

... regarding how ECM microstructure participates in the transmission of mechanical load information from a global (tissue or construct) level to a level local to the resident cells ultimately initiating relevant mechanotransduction pathways. In this study, the transmission of mechanical strains at various...

... engineering cone-and-plate viscometer bioreactor shear stress heart valve tissue engineering mechanotransduction Balachandran , K. , Konduri , S. , Sucosky , P. , Jo , H. , and Yoganathan , A. P. , 2006 , “ An Ex Vivo Study of the Biological Properties of Porcine...

..., and a time constant of 1.32±0.65 s. To our knowledge, this is the first time that stress-controlled indentation testing has been applied at the single cell level. This methodology represents a new tool in understanding the mechanical nature of anchorage-dependent cells and mechanotransductional pathways...

... Chondrocyte Mechanotransduction Articular cartilage serves as the resilient load-bearing surface at the ends of long bones in diarthroidal joints. Cartilage contains a single population of cells, known as chondrocytes, which are responsible for the turnover and maintenance of the extracellular matrix...

..., and Clinical Principles , Oxford Press, New York. Davies , P. F. , 1995 , “ Flow-mediated Endothelial Mechanotransduction ,” Physiol. Rev. , 75 ( 3 ), pp. 519 – 560...

... Mechanotransduction Articular cartilage serves as the resilient load-bearing surface at the ends of long bones in diarthroidal joints. Cartilage contains a single population of cells, known as chondrocytes, which are responsible for the turnover and maintenance of the extracellular matrix. In addition...