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Keywords: Shear Stress
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Journal Articles
Article Type: Research-Article
J Biomech Eng. January 2023, 145(1): 011001.
Paper No: BIO-21-1298
Published Online: August 19, 2022
... responses to curvature mediated flow. We show that flow patterns induced by parent vessel curvature produce changes in wall shear stress (WSS) and wall shear stress gradients (WSSG) that are correlated with differences in cell morphology and cellular protein localization. Cells in higher WSS regions align...
Includes: Supplementary data
Journal Articles
Article Type: Research-Article
J Biomech Eng. April 2019, 141(4): 041004.
Paper No: BIO-17-1598
Published Online: February 15, 2019
...Hamed Avari; Kem A. Rogers; Eric Savory Cardiovascular diseases (CVDs) are the number one cause of death globally. Arterial endothelial cell (EC) dysfunction plays a key role in many of these CVDs, such as atherosclerosis. Blood flow-induced wall shear stress (WSS), among many other...
Journal Articles
Article Type: Research-Article
J Biomech Eng. February 2019, 141(2): 021012.
Paper No: BIO-18-1238
Published Online: December 12, 2018
...Sascha Gross-Hardt; Fiete Boehning; Ulrich Steinseifer; Thomas Schmitz-Rode; Tim A. S. Kaufmann The reduction of excessive, nonphysiologic shear stresses leading to blood trauma can be the key to overcome many of the associated complications in blood recirculating devices. In that regard...
Journal Articles
Article Type: Research-Article
J Biomech Eng. December 2018, 140(12): 121006.
Paper No: BIO-18-1037
Published Online: September 25, 2018
... blood flow velocity and fluid wall shear stress, but also changed shear stress patterns. The presence of the plaque significantly reduced vascular wall tensile strain. Compared to the coronary artery models developed previously, the current model had improved physiological relevance. Transient...
Journal Articles
Article Type: Research-Article
J Biomech Eng. December 2013, 135(12): 121009.
Paper No: BIO-13-1014
Published Online: November 6, 2013
...Jiafeng Zhang; Xiaobing Chen; Jun Ding; Katharine H. Fraser; M. Ertan Taskin; Bartley P. Griffith; Zhongjun J. Wu Blood flow with different Re through square, diagonal, and random and 3D fiber arrays with the same porosity are studied in this paper. The local shear stress is found to vary...
Journal Articles
Article Type: Research Papers
J Biomech Eng. December 2011, 133(12): 121004.
Published Online: December 21, 2011
...Jennifer K. W. Chesnutt; Hai-Chao Han Tortuous blood vessels are often seen in humans in association with thrombosis, atherosclerosis, hypertension, and aging. Vessel tortuosity can cause high fluid shear stress, likely promoting thrombosis. However, the underlying physical mechanisms...
Journal Articles
Article Type: Research Papers
J Biomech Eng. April 2011, 133(4): 041002.
Published Online: February 17, 2011
... confined flow error analysis haemorheology health and safety jets nozzles prosthetics turbulence viscosity particle image velocimetry computational fluid dynamics FDA critical path initiative sudden expansion shear stress transitional flow turbulent flow measurement...
Journal Articles
Article Type: Research Papers
J Biomech Eng. June 2010, 132(6): 061004.
Published Online: April 21, 2010
...Saravan Kumar Shanmugavelayudam; David A. Rubenstein; Wei Yin Shear stress plays a pivotal role in pathogenesis of coronary heart disease. The spatial and temporal variation in hemodynamics of blood flow, especially shear stress, is dominated by the vessel geometry. The goal of the present study...
Journal Articles
Article Type: Research Papers
J Biomech Eng. April 2010, 132(4): 041005.
Published Online: March 17, 2010
... and FGF-2 in 3D culture. In conclusion, gene expression is different between 2D and 3D osteoblast cultures under static conditions. Additionally, osteoblasts respond to shear stress differently in 2D and 3D cultures. Our results highlight the importance of 3D mechanotransduction studies for bone tissue...
Journal Articles
Article Type: Research Papers
J Biomech Eng. September 2009, 131(9): 091007.
Published Online: August 6, 2009
... hallux valgus (HaV) and rheumatoid arthritis (RA) patients. Due to the absence of commercial devices capable of measuring shear stress distribution, a number of linear models were developed. All of these have met with limited success. This study used nonlinear methods, specifically neural network...
Journal Articles
Article Type: Research Papers
J Biomech Eng. September 2009, 131(9): 091004.
Published Online: August 4, 2009
... neurophysiology non-Newtonian flow pulsatile flow non-Newtonian fluid intracranial aneurysm shear stress ellipticity computational fluid dynamics rupture Aneurysms, local dilations of arterial walls, may continue to expand until rupture, causing hemorrhage, complications of local organ...
Journal Articles
Article Type: Design Innovations
J Biomech Eng. June 2008, 130(3): 035001.
Published Online: April 22, 2008
...Philippe Sucosky; Muralidhar Padala; Adnan Elhammali; Kartik Balachandran; Hanjoong Jo; Ajit P. Yoganathan Mechanical forces are known to affect the biomechanical properties of native and engineered cardiovascular tissue. In particular, shear stress that results from the relative motion of heart...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. December 2006, 128(6): 852–856.
Published Online: May 16, 2006
...Heather A. Himburg; Morton H. Friedman Background . Temporal variations in shear stress have been suggested to affect endothelial cell biology. To better quantify the range of dynamic shear forces that occur in vivo, the frequency content of shear variations that occur naturally over a cardiac...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. December 2006, 128(6): 965–968.
Published Online: May 16, 2006
... shear stress. Results. The results indicate that higher shears promote a more atheroprotective expression phenotype in porcine arterial endothelium. Conclusion. Statistical hemodynamics provides a realistic estimate of the hemodynamic stress on vascular tissue that can be correlated against biological...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. October 2006, 128(5): 777–781.
Published Online: April 28, 2006
...Shigeru Tada; Ken Okazaki This study demonstrates that aequorin, a luminescent natural dye, is useful for vascular cell intracellular C a 2 + concentration ( [ C a 2 + ] i ) determination. A new single-photon counting technique was developed to resolve the effects of fluid flow shear stress on [ C...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. August 2006, 128(4): 516–526.
Published Online: February 3, 2006
... and wall shear stress in the aneurysm are hypothesized to be correlated with its continuous expansion and eventual rupture. In addition, the assessment of the velocity field in the aneurysm dome and neck is important for the correct placement of endovascular coils. This paper describes the flow dynamics...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. April 2006, 128(2): 185–193.
Published Online: November 15, 2005
...Yan Zeng; Thong-See Lee; Peng Yu; Partha Roy; Hong-Tong Low Microchannel bioreactors have been used in many studies to manipulate and investigate the fluid microenvironment around cells. In this study, substrate concentrations and shear stresses at the base were computed from a three-dimensional...
Journal Articles
Article Type: Design Innovations
J Biomech Eng. April 2006, 128(2): 271–278.
Published Online: October 20, 2005
...Jordan Leyton-Mange; Sung Yang; Meghan H. Hoskins; Robert F. Kunz; Jeffrey D. Zahn; Cheng Dong Experimental models that mimic the flow conditions in microcapillaries have suggested that the local shear stresses and shear rates can mediate tumor cell and leukocyte arrest on the endothelium...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. February 2002, 124(1): 37–43.
Published Online: October 2, 2001
... an intensity gradient method, we demonstrated that SMC aligned in the direction perpendicular to applied shear stress, which contrasts with parallel alignment of endothelial cells under flow. SMC alignment varied with the magnitude of and exposure time to shear stress and is a continuous process...