...Sarah K. Van Houten; Michael T. K. Bramson; David T. Corr Bioreactors are commonly used to apply biophysically relevant stimulations to tissue-engineered constructs in order to explore how these stimuli influence tissue development, healing, and homeostasis, and they offer great flexibility because...

... to repair due to their avascularity, and limited clinical repair and replacement options exist. Tissue engineering has been proposed as a route to repair and replace fibrocartilages. Using the knee meniscus and TMJ disc as examples, this review describes how fibrocartilages can be engineered toward...

...Shuo Zhang; Sanjairaj Vijayavenkataraman; Geng Liang Chong; Jerry Ying Hsi Fuh; Wen Feng Lu Nerve guidance conduits (NGCs) are tubular tissue engineering scaffolds used for nerve regeneration. The poor mechanical properties and porosity have always compromised their performances for guiding...

... variables. The predicted values were used to determine the Pareto optimal set of engineering inputs to minimize peak contact stresses in the targeted population of subjects. tissue engineering Bayesian calibration computational simulator prediction meniscal design Kriging Knee menisci...

... for his expertise and help in confocal imaging. References [1] Langer , R. , and Vacanti , J. P. , 1993 , “ Tissue Engineering ,” Science , 260 ( 5110 ), pp. 920 – 926 . 10.1126/science.8493529 [2] Tang , Q. O. , Carasco , C. F. , Gamie , Z. , Korres , N...

... Cartilage Among Locations in the Adult Human Knee ,” Osteoarthritis Cartilage , 13 ( 8 ), pp. 672 – 678 . 10.1016/j.joca.2005.04.011 [53] Sander , E. A. , and Barocas , V. H. , 2008 , “ Biomimetic Collagen Tissues: Collagenous Tissue Engineering and Other Applications ,” Collagen , P...

... to simplify the evaluation of scaffold diffusivity. It is essential to increase the scaffold size for clinical application in tissue-engineering while preventing the necrosis of cells. To successfully regenerate a large-volume tissue, the scaffold must ensure sufficient oxygen delivery. The effective...

...Victor K. Lai; Spencer P. Lake; Christina R. Frey; Robert T. Tranquillo; Victor H. Barocas Fibrin and collagen, biopolymers occurring naturally in the body, are biomaterials commonly-used as scaffolds for tissue engineering. How collagen and fibrin interact to confer macroscopic mechanical...

... 21 12 2011 27 12 2011 21 12 2011 biological fluid dynamics bone cellular biophysics computational fluid dynamics micromechanics prosthetics tissue engineering Total hip replacement (THR) aseptic loosening osteolysis capsular pressure micromotion periprosthetic...

... Matrigel fibroblast atomic force microscopy biomechanics cellular biophysics elasticity tissue engineering Young's modulus References 1 Aguayo-Mazzucato , C. , and Bonner-Weir , S. , 2010 , “ Stem Cell Therapy for Type 1 Diabetes Mellitus ,” Nat. Rev. Endocrinol. , 6 ( 3...

.... Human tissue is both heterogeneous and anisotropic. An ultimate goal for many tissue engineering researchers is to best reproduce this complex anatomical environment by artificial means. To reproduce this environment, say in an attempt to replicate the transition between cortical bone to trabecular bone...

... 2011 11 10 2011 11 10 2011 biochemistry biological fluid dynamics bioreactors bone cellular biophysics foams macromolecules molecular biophysics orthopaedics porous materials proteins pulsatile flow tissue engineering mesenchymal stem cells PLGA pulsatile perfusion...

...Tai-Yi Yuan; Chun-Yuh Huang; Wei Yong Gu The goal of tissue engineering is to use substitutes to repair and restore organ function. Bioreactors are an indispensable tool for monitoring and controlling the unique environment for engineered constructs to grow. However, in order to determine...

...Kirsten R. C. Kinneberg; Marc T. Galloway; David L. Butler; Jason T. Shearn Previous studies by our laboratory have demonstrated that implanting a stiffer tissue engineered construct at surgery is positively correlated with repair tissue stiffness at 12 weeks. The objective of this study...

... engineering Young's modulus tissue engineering bone scaffolds cellular solids geometry projection numerical homogenization micro-robotic deposition Natural and synthetic bone graft materials, or scaffolds, are used in a range of orthopedic, cranio and maxillofacial applications to treat...

... towards controllable shear-induced erosion. biomechanics biomedical materials elastic constants permeability polymers tissue engineering wall shear stress topology optimization scaffold biofluid biodegradation As a fundamental premise of tissue engineering, scaffold is expected...

...Ana L. F. Soares; Maria Stekelenburg; Frank P. T. Baaijens Mechanical loading protocols in tissue engineering (TE) aim to improve the deposition of a properly organized collagen fiber network. In addition to collagen remodeling, these conditioning protocols can result in tissue compaction. Tissue...

...Cédric P. Laurent; Jean-François Ganghoffer; Jérôme Babin; Jean-Luc Six; Xiong Wang; Rachid Rahouadj Tissue engineering offers an interesting alternative to current anterior cruciate ligament (ACL) surgeries. Indeed, a tissue-engineered solution could ideally overcome the long-term complications...

... was developed to investigate cell-matrix interactions under unconfined compression conditions, using a tissue engineered encapsulating hydrogel seeded with chondrocytes. Model predictions of stress and strain distributions within the cell and on the cell boundary were shown to exhibit space-dependent responses...

... the transport of a relatively large neutral species (negligible osmotic fluid flux) in highly deformable hydrated soft tissues and tissue-engineered materials. 12 03 2010 13 01 2011 20 01 2011 18 02 2011 18 02 2011 biological tissues biomechanics deformation elasticity...