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Keywords: drug delivery
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Journal Articles
Article Type: Research-Article
J Biomech Eng. November 2022, 144(11): 111003.
Paper No: BIO-21-1376
Published Online: June 16, 2022
...Jason N. Mehta; Brianna E. Morales; Fang-Chi Hsu; John H. Rossmeisl; Christopher G. Rylander Convection-enhanced delivery (CED) has been extensively studied for drug delivery to the brain due to its inherent ability to bypass the blood-brain barrier. Unfortunately, CED has also been shown...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. April 2011, 133(4): 044502.
Published Online: February 18, 2011
... of in vivo tissues. Such FEMs will provide basic understanding of normal and pathological tissue responses and lead to optimization of local drug delivery strategies. We present a coupled porohyperelastic mass transport (PHEXPT) finite element approach developed using a commercially available ABAQUS finite...
Journal Articles
Article Type: Research Papers
J Biomech Eng. October 2010, 132(10): 101003.
Published Online: September 28, 2010
...R. A. Guha; N. H. Shear; M. Papini The impact and penetration of high speed particles with the human skin is of interest for targeted drug delivery by transdermal powder injection. However, it is often difficult to perform penetration experiments on dermal tissue using micron scale particles...
Journal Articles
Article Type: Research Papers
J Biomech Eng. July 2009, 131(7): 071007.
Published Online: July 16, 2009
... distributions following CED into the spinal cord. Quantification of these transport fields provides an important step toward development of drug-specific transport models of infusion. 06 11 2008 26 05 2009 16 07 2009 biological tissues biomedical MRI biotransport brain drug delivery...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074513.
Published Online: June 29, 2009
... pump out cytotoxic drugs from the intracellular space. In this study, we tested a hypothesis that freezing and thawing (F/T) may enhance intracellular drug delivery to MDR cancer cells via F/T-induced denaturation of MDR-associated proteins and/or membrane permeabilization. After a human MDR cancer...
Journal Articles
Article Type: Research Papers
J Biomech Eng. February 2009, 131(2): 021010.
Published Online: December 10, 2008
... for the development of computational tools, e.g., for the optimization of intrathecal drug delivery and computer-aided evaluation of cerebral pathologies such as syrinx development in syringomelia. Velocity profiles at the boundaries as obtained using velocimetric MRI at ( a ) the pontine cistern, ( b...
Journal Articles
Article Type: Research Papers
J Biomech Eng. February 2008, 130(1): 011015.
Published Online: February 20, 2008
...Frank E. Fresconi; Ajay K. Prasad The adverse health effects of inhaled particulate matter from the environment depend on its dispersion, transport, and deposition in the human airways. Similarly, precise targeting of deposition sites by pulmonary drug delivery systems also relies on characterizing...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 733–742.
Published Online: February 22, 2007
... biodiffusion blood vessels drug delivery systems haemodynamics physiological models polymer films drug eluting stents drug delivery diffusion therapeutic window restenosis Drug eluting stents (DESs) are coated with drugs that inhibit smooth muscle cells and myofibroblasts replication...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 722–732.
Published Online: February 18, 2007
...), could also be better understood through a detailed study of the flow in the lungs. respiratory airway bifurcation lung flow secondary velocity aerosol transport dispersion drug delivery aerosols bifurcation convection fluid oscillations lung pneumodynamics toxicology 15...