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Keywords: permeability
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Journal Articles
Article Type: Research Papers
J Biomech Eng. April 2012, 134(4): 041003.
Published Online: April 6, 2012
... the delivery of therapeutic agents to tumors. To elucidate the quantitative relationship between the vessel-wall compliance and permeability and the blood-flow rate in the microvessels of the tumor tissue, the tumor tissue with the normalized vasculature, and the normal tissue, we developed a transport model...
Journal Articles
Article Type: Research Papers
J Biomech Eng. August 2011, 133(8): 081008.
Published Online: September 19, 2011
... process. The effective stiffness and permeability of initial and optimized scaffold microstructures are characterized by the finite element based homogenization technique to quantify the variations of mechanical properties of scaffold during erosion. The illustrative examples show that a uniform WSS...
Journal Articles
Article Type: Research Papers
J Biomech Eng. July 2011, 133(7): 071006.
Published Online: July 18, 2011
... and the applied preload were different. The Young’s modulus was calculated from a viscoelastic model, and the permeability from a linear biphasic poroviscoelastic model. Important differences were observed in the prediction of the mechanical properties of the IVD according to the initial experimental conditions...
Journal Articles
Article Type: Research Papers
J Biomech Eng. June 2011, 133(6): 061005.
Published Online: June 21, 2011
... arthroscopic device, and by stress relaxation tests in unconfined compression geometry of isolated cartilage disks, providing the streaming potential integral (SPI), fibril modulus (Ef), matrix modulus (Em), and permeability (k). Histological sections were stained with Safranin-O and adjacent unstained...
Journal Articles
Article Type: Research Papers
J Biomech Eng. May 2011, 133(5): 051007.
Published Online: April 28, 2011
... is important both for the post-treatment mechanical loading and the risk of intraoperative extraosseous leakage. We have developed a computational model that describes the flow of biomaterials in porous bone structures by considering the material porosity, the region-dependent intrinsic permeability...
Journal Articles
Article Type: Research Papers
J Biomech Eng. February 2011, 133(2): 021002.
Published Online: January 24, 2011
... endothelial cells. Due to their glycosaminoglycan compositions, they carry negative charge under physiological conditions. To investigate the charge effect of the SGL and BM on the BBB permeability to charged solutes, we developed an electrodiffusion model for the transport of charged molecules across the BBB...
Journal Articles
Article Type: Research Papers
J Biomech Eng. November 2010, 132(11): 111004.
Published Online: October 15, 2010
... constitutive relations for anisotropic transport properties under finite deformation is lacking in the literature. This study presents an approach based on representation theorems for symmetric tensor-valued functions and provides conditions to enforce positive semidefiniteness of the permeability...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. October 2010, 132(10): 104502.
Published Online: September 27, 2010
... hydraulic permeabilities affect luminal interstitial fluid velocities and wall stresses within an AAA. A corresponding hyperelastic (HE) simulation was also run in order to be able to compare stress values between PHE and HE simulations. The effect of AAA size on local interstitial fluid velocity was also...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. June 2010, 132(6): 064502.
Published Online: April 26, 2010
... electromechanical measurements and unconfined compression testing on 3 mm diameter disks were used to assess cartilage properties, including the streaming potential integral (SPI), fibril modulus (Ef), matrix modulus (Em), and permeability ( k ) . Cartilage disks were also examined histologically. Compared...
Journal Articles
Article Type: Research Papers
J Biomech Eng. June 2010, 132(6): 061006.
Published Online: April 22, 2010
... an important computational need in the biomechanics of porous-permeable soft tissues. Placing the source code in the public domain provides a useful resource to the biomechanics community. In principle, any desired integration scheme may be implemented in the evaluation of Eqs. 45 , 47...
Journal Articles
Article Type: Research Papers
J Biomech Eng. October 2009, 131(10): 101007.
Published Online: September 2, 2009
...Gaffar Gailani; Mohammed Benalla; Rashal Mahamud; Stephen C. Cowin; Luis Cardoso Permeability of the mineralized bone tissue is a critical element in understanding fluid flow occurring in the lacunar-canalicular porosity (PLC) compartment of bone and its role in bone nutrition...
Journal Articles
Article Type: Research Papers
J Biomech Eng. October 2009, 131(10): 101005.
Published Online: September 2, 2009
... was supplemented with Evan's blue dye-labeled albumin. A custom tissue processing protocol was used to determine the spatial distribution of endothelial permeability, apoptosis, and proliferation. Finite element and computational fluid dynamics techniques were used to determine the mural and shear stress...
Journal Articles
Article Type: Research Papers
J Biomech Eng. July 2009, 131(7): 071007.
Published Online: July 16, 2009
... systems neurophysiology convection-enhanced delivery (CED) diffusion tensor imaging (DTI) drug delivery computational fluid dynamics (CFD) mathematical modeling permeability hydraulic conductivity intraparenchymal infusion In central nervous tissues, direct intraparenchymal infusion...
Journal Articles
Article Type: Research Papers
J Biomech Eng. August 2009, 131(8): 081005.
Published Online: July 2, 2009
... model (BPVE) from confined compression-stress relaxation measurements to extract the strain dependent hydraulic permeability variation and cone-plate rheometer measurements to obtain the flow-independent viscoelastic constants for the solid-matrix phase. The model is then applied to simulate...
Journal Articles
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074513.
Published Online: June 29, 2009
... cellular biophysics drug delivery systems freezing melting molecular biophysics permeability proteins multidrug resistance drug delivery freezing quantitative fluorescence microscopy Multidrug resistance (MDR) of cancer cells impairs the efficacy of chemotherapy by decreasing...
Journal Articles
Article Type: Research Papers
J Biomech Eng. April 2009, 131(4): 041008.
Published Online: February 3, 2009
... problems cellular biophysics finite element analysis mathematics computing medical computing molecular biophysics permeability physiological models proteins tissue engineering growth cartilage mixture permeation bioreactor finite element analysis In memory of Walter D. Pilkey...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 688–694.
Published Online: February 14, 2007
... to subzero temperatures at 5 ° C ∕ min . As the tissues were being frozen, a shape-independent differential scanning calorimeter technique was used to measure water loss from the tissues and, consequently, the best fit membrane permeability parameters ( L p g and E L p ) of ovarian tissues during freezing...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. October 2007, 129(5): 703–711.
Published Online: December 11, 2006
... volume fraction in the DMSO-laden stream, and cell membrane permeability parameter. Smaller depth fractions led to faster DMSO extraction but channel widths that were not practical. Higher Peclet numbers led to longer channels but smaller widths. For the Peclet values and channel depths considered...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. August 2007, 129(4): 503–510.
Published Online: November 20, 2006
... represented as a hydrated gel surrounded by a semi-permeable membrane, with the gel and membrane potentially exhibiting different properties. To help assess whether this more elaborate model of the cell is justified, this study investigates the response of spherical gels to osmotic loading, both from...
Journal Articles
Article Type: Technical Papers
J Biomech Eng. June 2007, 129(3): 405–412.
Published Online: November 8, 2006
...Gerard A. Ateshian; Benjamin J. Ellis; Jeffrey A. Weiss Porous-permeable tissues have often been modeled using porous media theories such as the biphasic theory. This study examines the equivalence of the short-time biphasic and incompressible elastic responses for arbitrary deformations...