... environments for bone remodeling during spinal fusion process. A design space optimization-topology optimization based algorithm was utilized to numerically reproduce the mechano-driven bone ingrowth process under three daily load cases, and the fusion outcomes were analyzed in terms of bone morphological...

... towards controllable shear-induced erosion. biomechanics biomedical materials elastic constants permeability polymers tissue engineering wall shear stress topology optimization scaffold biofluid biodegradation As a fundamental premise of tissue engineering, scaffold is expected...

... accurately simulate physiological bone-remodeling processes. As another approach, topology optimization originally devised in structural optimization has been also used in the computational simulation of the bone-remodeling process. The topology optimization method systematically and iteratively distributes...