Double-layered microcapsules, which usually consist of a core (polymeric) matrix surrounded by a (polymeric) shell, have been used in many industrial and scientific applications, such as microencapsulation of drugs and living cells. Concentric compound nozzle-based jetting has been favored due to its efficiency and precise control of the core-shell compound structure. Thus far, little is known about the underlying formation mechanism of double-layered microcapsules in compound nozzle jetting. This study aims to understand the formability of double-layered microcapsules in compound nozzle jetting by combining a theoretical analysis and numerical simulations. A linear temporal instability analysis is used to define the perturbation growth rates of stretching and squeezing modes and a growth ratio as a function of the wave number, and a computational fluid dynamics (CFD) method is implemented to model the microcapsule formation process in order to determine the good microcapsule forming range based on the growth ratio curve. Using a pseudobisection method, the lower and upper bounds of the good formability range have been determined for a given materials-nozzle system. The proposed formability prediction methodology has been implemented to model a water-poly (lactide-co-glycolide) (PLGA)-air compound jetting system.
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and Cell Biology,
Medical University of South Carolina,
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Research-Article
Methodology for the Evaluation of Double-Layered Microcapsule Formability Zone in Compound Nozzle Jetting Based on Growth Rate Ratio
Roger Markwald
and Cell Biology,
Medical University of South Carolina,
Roger Markwald
Department of Regenerative Medicine
and Cell Biology,
Medical University of South Carolina,
Charleston
, SC 29425
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Yong Huang
Roger Markwald
Department of Regenerative Medicine
and Cell Biology,
Medical University of South Carolina,
Charleston
, SC 29425
1Corresponding author.
Manuscript received May 31, 2012; final manuscript received January 4, 2013; published online April 8, 2013. Assoc. Editor: Ye Zhou.
J. Fluids Eng. May 2013, 135(5): 051203 (8 pages)
Published Online: April 8, 2013
Article history
Received:
May 31, 2012
Revision Received:
January 4, 2013
Citation
Wang, W., Leigh Herran, C., Coutris, N., Huang, Y., Mironov, V., and Markwald, R. (April 8, 2013). "Methodology for the Evaluation of Double-Layered Microcapsule Formability Zone in Compound Nozzle Jetting Based on Growth Rate Ratio." ASME. J. Fluids Eng. May 2013; 135(5): 051203. https://doi.org/10.1115/1.4023646
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