Glaucoma, one of the leading causes of blindness worldwide, is caused mainly by the disruption of the retinal ganglion cell axons in the lamina cribrosa (LC), a structure within the optic nerve head (ONH) [1]. Although elevated intraocular pressure (IOP) is widely accepted as an important risk factor for glaucoma, recent studies have demonstrated that an elevated IOP does not necessarily cause the development of this disease [2]. The optic nerve is not only exposed to IOP in the eye but also to the intracranial pressure (ICP), as it is surrounded by the cerebrospinal fluid in the subarachnoid space. However, the deformation responses of ONH tissues to acute increases in ICP are not clear.

The aim of this work was to systematically investigate ICP-related lamina cribrosa deformation (LCD) and scleral canal expansion (SCE). Specifically, a 2D finite element (FE) model of the ONH was developed to...

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