To develop and evaluate the clinical application of a multimodal colposcopy combining multispectral reflectance, autofluorescence, and red, green, blue (RGB) imaging for noninvasive characterization of cervical intraepithelial neoplasia (CIN). We developed a multimodal colposcopy system that combined multispectral reflectance, autofluorescence, and RGB imaging for noninvasive characterization of CIN. We studied the optical properties of cervical tissue first; then the imaging system was designed and tested in a clinical trial where comprehensive datasets were acquired and analyzed to differentiate between squamous normal and high grade types of cervical tissue. The custom-designed multimodal colposcopy is capable of acquiring multispectral reflectance images, autofluorescence images, and RGB images of cervical tissue consecutively. The classification algorithm was employed on both normal and abnormal cases for image segmentation. The performance characteristics of this system were comparable to the gold standard histopathologic measurements with statistical significance. Our pilot study demonstrated the clinical potential of this multimodal colposcopic system for noninvasive characterization of CIN. The proposed system was simple, noninvasive, cost-effective, and portable, making it a suitable device for deployment in developing countries or rural regions of limited resources.
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September 2017
Research-Article
Development of a Multimodal Colposcopy for Characterization of Cervical Intraepithelial Neoplasia
Wenqi Ren,
Wenqi Ren
Department of Precision Machinery
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: rwq1112@mail.ustc.edu.cn
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: rwq1112@mail.ustc.edu.cn
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Yingjie Qu,
Yingjie Qu
Department of Precision Machinery
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: 1554046929@qq.com
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: 1554046929@qq.com
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Jiaojiao Pei,
Jiaojiao Pei
Department of Obstetrics and Gynecology,
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: 852975628@qq.com
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: 852975628@qq.com
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Linlin Xiao,
Linlin Xiao
Department of Obstetrics and Gynecology,
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: xiaolinlinrachel@sina.com
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: xiaolinlinrachel@sina.com
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Shiwu Zhang,
Shiwu Zhang
Department of Precision Machinery and
Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: swzhang@ustc.edu.cn
Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: swzhang@ustc.edu.cn
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Shufang Chang,
Shufang Chang
Department of Obstetrics and Gynecology,
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: shfch2005@163.com
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: shfch2005@163.com
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Ronald X. Xu
Ronald X. Xu
Department of Precision Machinery
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China;
Department of Biomedical Engineering,
The Ohio State University,
Columbus, OH 43210
e-mail: xu.202@osu.edu
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China;
Department of Biomedical Engineering,
The Ohio State University,
Columbus, OH 43210
e-mail: xu.202@osu.edu
Search for other works by this author on:
Wenqi Ren
Department of Precision Machinery
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: rwq1112@mail.ustc.edu.cn
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: rwq1112@mail.ustc.edu.cn
Yingjie Qu
Department of Precision Machinery
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: 1554046929@qq.com
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: 1554046929@qq.com
Jiaojiao Pei
Department of Obstetrics and Gynecology,
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: 852975628@qq.com
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: 852975628@qq.com
Linlin Xiao
Department of Obstetrics and Gynecology,
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: xiaolinlinrachel@sina.com
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: xiaolinlinrachel@sina.com
Shiwu Zhang
Department of Precision Machinery and
Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: swzhang@ustc.edu.cn
Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China
e-mail: swzhang@ustc.edu.cn
Shufang Chang
Department of Obstetrics and Gynecology,
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: shfch2005@163.com
Second Affiliated Hospital of Chongqing
Medical University,
Chongqing 400010, China
e-mail: shfch2005@163.com
Ronald X. Xu
Department of Precision Machinery
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China;
Department of Biomedical Engineering,
The Ohio State University,
Columbus, OH 43210
e-mail: xu.202@osu.edu
and Precision Instrumentation,
University of Science and Technology of China,
Hefei 230027, China;
Department of Biomedical Engineering,
The Ohio State University,
Columbus, OH 43210
e-mail: xu.202@osu.edu
1Corresponding authors.
Manuscript received July 15, 2016; final manuscript received February 12, 2017; published online June 27, 2017. Assoc. Editor: Chris Rylander.
J. Med. Devices. Sep 2017, 11(3): 031005 (10 pages)
Published Online: June 27, 2017
Article history
Received:
July 15, 2016
Revised:
February 12, 2017
Citation
Ren, W., Qu, Y., Pei, J., Xiao, L., Zhang, S., Chang, S., and Xu, R. X. (June 27, 2017). "Development of a Multimodal Colposcopy for Characterization of Cervical Intraepithelial Neoplasia." ASME. J. Med. Devices. September 2017; 11(3): 031005. https://doi.org/10.1115/1.4036335
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