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Journal Articles

Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study

Adithya Gurumurthy, Clement Kleinstreuer

J Biomech Eng. November 2021, 143(11): 111001.

Paper No: BIO-21-1035

DOI: https://doi.org/10.1115/1.4051217

Published Online: July 14, 2021

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Topics: Aerosols, Drugs, Flow (Dynamics), Nanoparticles, Particulate matter, Lung, Diffusion (Physics), Fluids, Drug delivery systems

Journal Articles

A Lagrangian Approach for Calculating Microsphere Deposition in a One-Dimensional Lung-Airway Model

Mayank Vaish, Clement Kleinstreuer

J Biomech Eng. September 2015, 137(9): 094502.

Paper No: BIO-14-1557

DOI: https://doi.org/10.1115/1.4030977

Published Online: September 1, 2015

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Topics: Air flow, Flow (Dynamics), Lung, Particulate matter, Geometry

Proceedings Papers

DDPM-DEM Simulations of Particulate Flows in Human Tracheobronchial Airways

Yu Feng, Clement Kleinstreuer

Proc. ASME. IMECE2013, Volume 3B: Biomedical and Biotechnology Engineering, V03BT03A030, November 15–21, 2013

Paper No: IMECE2013-62307

DOI: https://doi.org/10.1115/IMECE2013-62307

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Topics: Discrete element methods, Engineering simulation, Flow (Dynamics), Particulate matter, Simulation, Computational fluid dynamics, Computer software, Fluids, Aerosols, Dynamics (Mechanics)

Journal Articles

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions—Part I: Whole-Lung Aerosol Dynamics

Arun V. Kolanjiyil, Clement Kleinstreuer

J Biomech Eng. December 2013, 135(12): 121003.

Paper No: BIO-13-1174

DOI: https://doi.org/10.1115/1.4025332

Published Online: October 9, 2013

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Topics: Dynamics (Mechanics), Flow (Dynamics), Lung, Nanoparticles, Particulate matter, Fluids

Journal Articles

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions—Part II: Multi-Compartmental Modeling

Arun V. Kolanjiyil, Clement Kleinstreuer

J Biomech Eng. December 2013, 135(12): 121004.

Paper No: BIO-13-1175

DOI: https://doi.org/10.1115/1.4025333

Published Online: October 9, 2013

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Topics: Lung, Nanoparticles, Particulate matter, Modeling, Clearances (Engineering), Mass transfer

Proceedings Papers

Transport and Deposition of Ellipsoidal Fibers in Subject-Specific Lung Airways

Yu Feng, Clement Kleinstreuer

Proc. ASME. IMECE2012, Volume 2: Biomedical and Biotechnology, 699-700, November 9–15, 2012

Paper No: IMECE2012-87032

DOI: https://doi.org/10.1115/IMECE2012-87032

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Topics: Fibers, Lung, Particulate matter, Nanoparticles, Air flow, Blood, Cancer, Composite materials, Computer simulation, Drugs

Proceedings Papers

A Relation Between Particle Hemodynamics and Intraluminal Thrombus Formation in Abdominal Aortic Aneurysms

Christopher A. Basciano, Julie H. Y. Ng, Ender A. Finol, Clement Kleinstreuer

Proc. ASME. SBC2009, ASME 2009 Summer Bioengineering Conference, Parts A and B, 943-944, June 17–21, 2009

Paper No: SBC2009-204721

DOI: https://doi.org/10.1115/SBC2009-204721

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Topics: Aneurysms, Hemodynamics, Particulate matter, Thrombosis, Blood, Aorta, Blood vessels, Kidney, Platelets, Proteins

Proceedings Papers

Computational Analysis of Thermal Performance and Entropy Generation of Nanofluid Flow in Microchannels

Jie Li, Clement Kleinstreuer, Yu Feng

Proc. ASME. MNHMT2012, ASME 2012 Third International Conference on Micro/Nanoscale Heat and Mass Transfer, 135-144, March 3–6, 2012

Paper No: MNHMT2012-75007

DOI: https://doi.org/10.1115/MNHMT2012-75007

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Topics: Entropy, Flow (Dynamics), Heat sinks, Microchannels, Nanofluids, Thermal conductivity

Proceedings Papers

Determination of Representative Pressure, Velocity and Flow Rate Waveforms in a Human Hepatic Artery System Afflicted With Metastatic Tumors

Christopher A. Basciano, Clement Kleinstreuer, Andrew S. Kennedy

Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 1097-1098, June 22–25, 2011

Paper No: SBC2011-53875

DOI: https://doi.org/10.1115/SBC2011-53875

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Topics: Flow (Dynamics), Liver, Pressure, Tumors, Patient treatment, Radiation (Physics), Ablation (Vaporization technology), Biological tissues, Blood flow, Surgery

Proceedings Papers

Aerosol Deposition Characteristics in Subject-Specific Tracheobroncheal Airways

Sinjae Hyun, Young-Eun Hyun, Katherine Birchard, Zhe Zhang, Clement Kleinstreuer

Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 205-206, June 16–19, 2010

Paper No: SBC2010-19171

DOI: https://doi.org/10.1115/SBC2010-19171

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Topics: Aerosols, Cavities, Collapse, Lung, Membranes, Pressure, Shapes, Trachea, Vocal cords

Proceedings Papers

Variations in Tracheobronchial Airway Morphology for Different Age Groups

Jason Ryans, Bennett Welch, Sinjae Hyun, Zhe Zhang, Clement Kleinstreuer

Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 667-668, June 16–19, 2010

Paper No: SBC2010-19452

DOI: https://doi.org/10.1115/SBC2010-19452

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Topics: Aerosols, Air flow, Cancer, Clearances (Engineering), Computer simulation, Diabetes, Diseases, Drug delivery systems, Drugs, Lung

Journal Articles

Critical Invalidation of Temperature Dependence of Nanofluid Thermal Conductivity Enhancement

Kisoo Han, Wook-Hyun Lee, Clement Kleinstreuer, Junemo Koo

J. Heat Transfer. May 2013, 135(5): 051601.

Paper No: HT-12-1435

DOI: https://doi.org/10.1115/1.4023544

Published Online: April 11, 2013

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Topics: Fluids, Nanofluids, Natural convection, Temperature, Thermal conductivity, Wire, Temperature effects, Transients (Dynamics), Water

Journal Articles

Computational Analysis of Non-Spherical Particle Transport and Deposition in Shear Flow With Application to Lung Aerosol Dynamics—A Review

Clement Kleinstreuer, Yu Feng

J Biomech Eng. February 2013, 135(2): 021008.

Paper No: BIO-12-1547

DOI: https://doi.org/10.1115/1.4023236

Published Online: February 7, 2013

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Topics: Particulate matter

Journal Articles

Thermal Nanofluid Property Model With Application to Nanofluid Flow in a Parallel Disk System—Part II: Nanofluid Flow Between Parallel Disks

Yu Feng, Clement Kleinstreuer

J. Heat Transfer. May 2012, 134(5): 051003.

DOI: https://doi.org/10.1115/1.4005633

Published Online: April 13, 2012

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Topics: Disks, Entropy, Flow (Dynamics), Friction, Nanofluids, Water, Temperature, Heat transfer, Nanoparticles, Pressure drop

Journal Articles

Thermal Nanofluid Property Model With Application to Nanofluid Flow in a Parallel-Disk System—Part I: A New Thermal Conductivity Model for Nanofluid Flow

Clement Kleinstreuer, Yu Feng

J. Heat Transfer. May 2012, 134(5): 051002.

DOI: https://doi.org/10.1115/1.4005632

Published Online: April 13, 2012

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Topics: Fluids, Nanofluids, Nanoparticles, Particulate matter, Temperature, Thermal conductivity, Water, Brownian motion

Journal Articles

Analysis of Multi-Layer Immiscible Fluid Flow in a Microchannel

Jie Li, Paul S. Sheeran, Clement Kleinstreuer

J. Fluids Eng. November 2011, 133(11): 111202.

DOI: https://doi.org/10.1115/1.4005134

Published Online: October 19, 2011

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Topics: Electroosmosis, Flow (Dynamics), Fluids, Microchannels, Pressure, Viscosity, Fluid dynamics

Journal Articles

Optimal Drug-Aerosol Delivery to Predetermined Lung Sites

Clement Kleinstreuer, Zhe Zhang

J. Heat Transfer. January 2011, 133(1): 011002.

DOI: https://doi.org/10.1115/1.4002224

Published Online: September 27, 2010

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Topics: Aerosols, Drops, Drugs, Flow (Dynamics), Lung, Particulate matter, Air flow, Mass transfer, Heat, Computer simulation

Journal Articles

Entropy Generation Analysis for Nanofluid Flow in Microchannels

Jie Li, Clement Kleinstreuer

J. Heat Transfer. December 2010, 132(12): 122401.

DOI: https://doi.org/10.1115/1.4002395

Published Online: September 17, 2010

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Topics: Entropy, Flow (Dynamics), Microchannels, Nanofluids, Water

Proceedings Papers

Analyses of Liquid Flow in Micro-Conduits

Junemo Koo, Clement Kleinstreuer

Proc. ASME. ICMM2004, ASME 2nd International Conference on Microchannels and Minichannels, 191-198, June 17–19, 2004

Paper No: ICMM2004-2334

DOI: https://doi.org/10.1115/ICMM2004-2334

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Topics: Flow (Dynamics), Energy dissipation, Reynolds number, Friction, Surface roughness, Fluids, Heat, Microchannels, Non-Newtonian fluids, Computers

Proceedings Papers

RBC Distribution in Stenosed Arterial Geometries Using Hematocrit Dependent Viscosity Model (HDVM)

Sinjae Hyun, Clement Kleinstreuer

Proc. ASME. IMECE2004, Advances in Bioengineering, 25-26, November 13–19, 2004

Paper No: IMECE2004-59948

DOI: https://doi.org/10.1115/IMECE2004-59948

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Topics: Viscosity, Shear rate, Engineering simulation, Simulation, Blood, Blood flow, Convection, Diffusion (Physics), Diseases, Erythrocytes

Journal citation

NARROW

Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study

A Lagrangian Approach for Calculating Microsphere Deposition in a One-Dimensional Lung-Airway Model

DDPM-DEM Simulations of Particulate Flows in Human Tracheobronchial Airways

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions—Part I: Whole-Lung Aerosol Dynamics

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions—Part II: Multi-Compartmental Modeling

Transport and Deposition of Ellipsoidal Fibers in Subject-Specific Lung Airways

A Relation Between Particle Hemodynamics and Intraluminal Thrombus Formation in Abdominal Aortic Aneurysms

Computational Analysis of Thermal Performance and Entropy Generation of Nanofluid Flow in Microchannels

Determination of Representative Pressure, Velocity and Flow Rate Waveforms in a Human Hepatic Artery System Afflicted With Metastatic Tumors

Aerosol Deposition Characteristics in Subject-Specific Tracheobroncheal Airways

Variations in Tracheobronchial Airway Morphology for Different Age Groups

Critical Invalidation of Temperature Dependence of Nanofluid Thermal Conductivity Enhancement

Computational Analysis of Non-Spherical Particle Transport and Deposition in Shear Flow With Application to Lung Aerosol Dynamics—A Review

Thermal Nanofluid Property Model With Application to Nanofluid Flow in a Parallel Disk System—Part II: Nanofluid Flow Between Parallel Disks

Thermal Nanofluid Property Model With Application to Nanofluid Flow in a Parallel-Disk System—Part I: A New Thermal Conductivity Model for Nanofluid Flow

Analysis of Multi-Layer Immiscible Fluid Flow in a Microchannel

Optimal Drug-Aerosol Delivery to Predetermined Lung Sites

Entropy Generation Analysis for Nanofluid Flow in Microchannels

Analyses of Liquid Flow in Micro-Conduits

RBC Distribution in Stenosed Arterial Geometries Using Hematocrit Dependent Viscosity Model (HDVM)

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