The heat transfer and fluid flow performance of a hybrid jet plus multipass microchannel heat sink in two-phase operation is evaluated for the cooling of a single large area, 3.61 cm2, heat source. The two-layer branching microchannel heat sink is evaluated using HFE-7100 as the coolant at three inlet volumetric flow rates of 150, 300, and 450 ml/min. The boiling performance is highest for the flow rate of 450 ml/min with the maximum heat flux value of 174 W/cm2. Critical heat flux (CHF) was observed at two of the tested flow rates, 150 and 300 ml/min, before reaching the maximum operating temperature for the serpentine heater. At 450 ml/min, the heater reached the maximum allowable temperature prior to observing CHF. The maximum pressure drop for the heat sink is 34.1 kPa at a heat flux of 164 W/cm2. Further, the peak heat transfer coefficient value of the heat sink is 28,700 W/m2 K at a heat flux value of 174 W/cm2 and a flow rate of 450 ml/min. Finally, a validated correlation of the single device cooler is presented that predicts heat transfer performance and can be utilized in the design of multidevice coolers.