This paper focuses on the influences of the discrete-hole shape and layout on the blade endwall film cooling effectiveness. The effect of upstream purge slot injection on the film cooling performance of the discrete hole was also investigated. The diffusion slot hole was first applied to the blade endwall. As a comparison, the cooling performance of the fan-shaped hole was also measured. Totally, six discrete-hole cooling configurations (two hole shapes × three layouts) were investigated. Experiments were performed in a seven-blade linear cascade with the exit Reynolds number of 2.64 × 105. The average blowing ratios (BR) of the discrete holes changed from 0.5 to 2.5, and the coolant mass flow ratio of the purge slot (MFR) was fixed at MFR = 1.5%. The distributions of the cooling effectiveness on the blade endwall were measured by the pressure-sensitive paint technique. Results indicate that the diffusion slot hole significantly increases the film cooling effectiveness on the blade endwall compared to the fan-shaped hole, especially at a high blowing ratio. The maximum relative increment of the cooling effectiveness is over 40%. The layout with the discrete holes arranged lining up with the tangent direction of the blade profile offset curves exhibits a comparable film cooling effectiveness with the layout with the discrete holes arranged according to the cross-flow direction. The film cooling effectiveness on the pressure surface corner is remarkably enhanced by deflecting the hole orientation angle toward the pressure surface. The combination of purge slot and diffusion slot holes supplies a full-coverage film cooling for the entire blade endwall at MFR = 1.5% and BR = 2.5. In addition, the slot injection leads to a non-negligible influence on the cooling performance of the discrete holes near the separation line.